TEA_010710 protein (Camellia sinensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TEA_010710

Cytokinin riboside 5'-monophosphate phosphoribohydrolase; Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms. (218 aa)

Predicted Functional Partners:

TEA_000692

0.877

TEA_019339

0.745

TEA_002734

0.745

TEA_027060

0.633

TEA_016537

0.633

TEA_016532

0.633

TEA_012269

0.633

TEA_009412

0.633

TEA_009856

0.622

TEA_003776

0.622

Your Current Organism:

Camellia sinensis

NCBI taxonomy Id: 542762
Other names: C. sinensis var. sinensis, Camellia sinensis var. sinensis

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TEA_000692	TEA_009856	A0A4S4DV04	A0A4S4E2Q9	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.522
TEA_000692	TEA_010710	A0A4S4DV04	A0A4S4DNF5	Uncharacterized protein.	Cytokinin riboside 5'-monophosphate phosphoribohydrolase; Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms.	0.877
TEA_002734	TEA_003776	A0A4S4EE27	A0A4S4E4U8	Uncharacterized protein.	Uncharacterized protein.	0.408
TEA_002734	TEA_010710	A0A4S4EE27	A0A4S4DNF5	Uncharacterized protein.	Cytokinin riboside 5'-monophosphate phosphoribohydrolase; Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms.	0.745
TEA_003776	TEA_002734	A0A4S4E4U8	A0A4S4EE27	Uncharacterized protein.	Uncharacterized protein.	0.408
TEA_003776	TEA_009412	A0A4S4E4U8	A0A4S4EYX3	Uncharacterized protein.	Uncharacterized protein.	0.972
TEA_003776	TEA_009856	A0A4S4E4U8	A0A4S4E2Q9	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.837
TEA_003776	TEA_010710	A0A4S4E4U8	A0A4S4DNF5	Uncharacterized protein.	Cytokinin riboside 5'-monophosphate phosphoribohydrolase; Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms.	0.622
TEA_003776	TEA_012269	A0A4S4E4U8	A0A4S4DHL9	Uncharacterized protein.	Uncharacterized protein.	0.972
TEA_003776	TEA_016532	A0A4S4E4U8	A0A4S4D9T3	Uncharacterized protein.	Uncharacterized protein.	0.969
TEA_003776	TEA_016537	A0A4S4E4U8	A0A4S4D9N5	Uncharacterized protein.	Uncharacterized protein.	0.969
TEA_003776	TEA_019339	A0A4S4E4U8	A0A4S4DYS8	Uncharacterized protein.	Uncharacterized protein.	0.408
TEA_003776	TEA_027060	A0A4S4E4U8	A0A4S4D6M3	Uncharacterized protein.	ARID domain-containing protein.	0.972
TEA_009412	TEA_003776	A0A4S4EYX3	A0A4S4E4U8	Uncharacterized protein.	Uncharacterized protein.	0.972
TEA_009412	TEA_010710	A0A4S4EYX3	A0A4S4DNF5	Uncharacterized protein.	Cytokinin riboside 5'-monophosphate phosphoribohydrolase; Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms.	0.633
TEA_009412	TEA_012269	A0A4S4EYX3	A0A4S4DHL9	Uncharacterized protein.	Uncharacterized protein.	0.832
TEA_009412	TEA_016532	A0A4S4EYX3	A0A4S4D9T3	Uncharacterized protein.	Uncharacterized protein.	0.758
TEA_009412	TEA_016537	A0A4S4EYX3	A0A4S4D9N5	Uncharacterized protein.	Uncharacterized protein.	0.758
TEA_009412	TEA_027060	A0A4S4EYX3	A0A4S4D6M3	Uncharacterized protein.	ARID domain-containing protein.	0.837
TEA_009856	TEA_000692	A0A4S4E2Q9	A0A4S4DV04	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.522

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.962

expected number of edges:

16

PPI enrichment p-value:

3.98e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046426

Negative regulation of receptor signaling pathway via JAK-STAT

4 of 11

2.76

3.32

6.97e-07

GO:0016032

Viral process

4 of 40

2.2

2.46

1.37e-05

GO:0006271

DNA strand elongation involved in DNA replication

3 of 18

2.42

1.93

0.00024

GO:0006270

DNA replication initiation

3 of 25

2.28

1.79

0.00040

GO:0044786

Cell cycle DNA replication

3 of 27

2.24

1.78

0.00041

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031462

Cul2-RING ubiquitin ligase complex

4 of 10

2.8

3.78

9.49e-08

GO:0070449

Elongin complex

3 of 8

2.77

2.69

1.13e-05

GO:0071162

CMG complex

3 of 11

2.63

2.55

1.87e-05

GO:0031461

cullin-RING ubiquitin ligase complex

5 of 122

1.81

2.34

4.72e-06

GO:0000228

Nuclear chromosome

4 of 130

1.68

1.7

0.00015

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7345

Cul2-RING ubiquitin ligase complex, and Cul5-RING ubiquitin ligase complex

5 of 10

2.9

5.12

2.88e-10

CL:7347

VCB complex, and Elongin-C

4 of 5

3.1

4.52

5.31e-09

CL:7219

Neddylation

6 of 81

2.07

3.79

4.12e-09

CL:6178

DNA replication initiation, and Activation of the pre-replicative complex

4 of 33

2.28

2.9

1.94e-06

CL:6187

MCM N-terminal domain, and Cdc6, C-terminal

2 of 5

2.8

1.52

0.0017

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04120

Ubiquitin mediated proteolysis

5 of 212

1.57

1.85

2.14e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1234176

Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha

5 of 55

2.16

3.19

2.67e-07

MAP-1234174

Cellular response to hypoxia

5 of 59

2.12

3.16

2.67e-07

MAP-69239

Synthesis of DNA

4 of 131

1.68

1.54

0.00039

MAP-69306

DNA Replication

4 of 142

1.65

1.52

0.00040

MAP-8951664

Neddylation

5 of 271

1.46

0.00020

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070449

Elongin complex

2 of 7

2.65

0.95

0.0188

GOCC:0042555

MCM complex

2 of 13

2.38

0.85

0.0274

GOCC:0000151

Ubiquitin ligase complex

3 of 147

1.51

0.65

0.0476

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0347

Helicase

2 of 36

1.94

0.73

0.0431

KW-0235

DNA replication

2 of 28

2.05

0.73

0.0431

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039948

Elongin-C

2 of 2

3.2

1.12

0.0095

IPR001232

S-phase kinase-associated protein 1-like

2 of 3

3.02

1.12

0.0095

IPR041562

MCM, AAA-lid domain

2 of 7

2.65

1.01

0.0147

IPR033762

MCM OB domain

2 of 8

2.59

1.01

0.0147

IPR027925

MCM N-terminal domain

2 of 6

2.72

1.01

0.0147

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (10%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About