STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TEA_005753Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. (560 aa)    
Predicted Functional Partners:
TEA_007323
Uncharacterized protein.
    
 0.999
TEA_025888
HORMA domain-containing protein.
   
  
 0.999
TEA_003791
Uncharacterized protein; Belongs to the thymidine kinase family.
  
 
 0.993
TEA_026275
Thymidine kinase.
  
 
 0.993
TEA_025066
Thymidine kinase.
  
 
 0.993
TEA_023444
Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.
  
 0.992
TEA_016182
dUTPase domain-containing protein.
  
 0.992
TEA_018812
Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...]
 
 
  0.989
TEA_005890
DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family.
   
  
 0.978
TEA_028166
dNK domain-containing protein.
  
 0.976
Your Current Organism:
Camellia sinensis
NCBI taxonomy Id: 542762
Other names: C. sinensis var. sinensis, Camellia sinensis var. sinensis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.