STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ligDNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (592 aa)    
Predicted Functional Partners:
pcn
Proliferating cell nuclear antigen, PCNA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
   
 0.984
ligA
DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
    
 0.946
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
 
 0.909
Htur_1499
KEGG: scl:sce5497 DNA polymerase II; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; SMART: DNA-directed DNA polymerase B.
 
 0.883
Htur_2634
KEGG: sat:SYN_00286 DNA polymerase IV; PFAM: PHP domain protein; helix-hairpin-helix motif; SMART: DNA polymerase X; phosphoesterase PHP domain protein; Helix-hairpin-helix DNA-binding class 1.
  
 0.870
Htur_3432
TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP domain protein; KEGG: ccv:CCV52592_0277 histidinol phosphate phosphatase, HisJ.
  
 0.870
polB
DNA-directed DNA polymerase; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family.
   
 
 0.821
Htur_2015
PFAM: type III restriction protein res subunit; helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; KEGG: mxa:MXAN_6101 putative helicase, ATP- dependent.
   
 
 0.777
rpoH
RNA polymerase Rpb5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.
 
  
  0.764
rfcL
AAA ATPase central domain protein; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily.
   
 0.729
Your Current Organism:
Haloterrigena turkmenica
NCBI taxonomy Id: 543526
Other names: H. turkmenica DSM 5511, Haloterrigena turkmenica ATCC 51198, Haloterrigena turkmenica DSM 5511, Haloterrigena turkmenica str. DSM 5511, Haloterrigena turkmenica strain DSM 5511
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