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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ACS17239.1Threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class I and II; KEGG: pna:Pnap_3651 threonine aldolase. (352 aa)    
Predicted Functional Partners:
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
    
 0.953
ACS17580.1
PFAM: glycine hydroxymethyltransferase; aminotransferase class I and II; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: sil:SPO3529 serine hydroxymethyltransferase.
   
 0.924
ACS18482.1
KEGG: pna:Pnap_2230 threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit.
  
 0.924
ACS19526.1
PFAM: aminotransferase class V; KEGG: dac:Daci_3052 serine--glyoxylate transaminase.
    
 0.924
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
   
 0.924
ACS20848.1
PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: cti:RALTA_B1800 putative pyridoxal-5'-phosphate-dependent enzyme, beta family; putative threonine synthase.
  
 0.924
ACS22049.1
PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: azc:AZC_1923 threonine aldolase.
  
  
 
0.915
ACS16812.1
TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; amino acid-binding ACT domain protein; KEGG: pna:Pnap_0111 threonine dehydratase.
  
 
 0.910
ACS17391.1
PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: dia:Dtpsy_3120 pyridoxal-5'-phosphate-dependent protein beta subunit.
  
 
 0.910
ilvA
Threonine dehydratase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.910
Your Current Organism:
Variovorax paradoxus S110
NCBI taxonomy Id: 543728
Other names: V. paradoxus S110, Variovorax paradoxus str. S110, Variovorax paradoxus strain S110
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