node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS20340.1 | ACS21896.1 | Vapar_3724 | Vapar_5294 | Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | KEGG: rfr:Rfer_4237 KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; SMART: CBS domain containing protein; Belongs to the SIS family. GutQ/KpsF subfamily. | 0.904 |
ACS20340.1 | kdsA | Vapar_3724 | Vapar_3444 | Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | TIGRFAM: 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: aav:Aave_1326 2-dehydro-3-deoxyphosphooctonate aldolase. | 0.866 |
ACS20340.1 | kdsB | Vapar_3724 | Vapar_2639 | Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.986 |
ACS20340.1 | lpxA | Vapar_3724 | Vapar_2611 | Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.866 |
ACS20340.1 | lpxB | Vapar_3724 | Vapar_2612 | Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.868 |
ACS20340.1 | lpxC | Vapar_3724 | Vapar_0925 | Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | UDP-3-0-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.867 |
ACS20340.1 | lpxD | Vapar_3724 | Vapar_2609 | Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.868 |
ACS20340.1 | lpxK | Vapar_3724 | Vapar_2641 | Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.992 |
ACS21896.1 | ACS20340.1 | Vapar_5294 | Vapar_3724 | KEGG: rfr:Rfer_4237 KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; SMART: CBS domain containing protein; Belongs to the SIS family. GutQ/KpsF subfamily. | Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 0.904 |
ACS21896.1 | kdsA | Vapar_5294 | Vapar_3444 | KEGG: rfr:Rfer_4237 KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; SMART: CBS domain containing protein; Belongs to the SIS family. GutQ/KpsF subfamily. | TIGRFAM: 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: aav:Aave_1326 2-dehydro-3-deoxyphosphooctonate aldolase. | 0.991 |
ACS21896.1 | kdsB | Vapar_5294 | Vapar_2639 | KEGG: rfr:Rfer_4237 KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; SMART: CBS domain containing protein; Belongs to the SIS family. GutQ/KpsF subfamily. | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.906 |
ACS21896.1 | lpxA | Vapar_5294 | Vapar_2611 | KEGG: rfr:Rfer_4237 KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; SMART: CBS domain containing protein; Belongs to the SIS family. GutQ/KpsF subfamily. | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.901 |
ACS21896.1 | lpxB | Vapar_5294 | Vapar_2612 | KEGG: rfr:Rfer_4237 KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; SMART: CBS domain containing protein; Belongs to the SIS family. GutQ/KpsF subfamily. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.902 |
ACS21896.1 | lpxC | Vapar_5294 | Vapar_0925 | KEGG: rfr:Rfer_4237 KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; SMART: CBS domain containing protein; Belongs to the SIS family. GutQ/KpsF subfamily. | UDP-3-0-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.901 |
ACS21896.1 | lpxD | Vapar_5294 | Vapar_2609 | KEGG: rfr:Rfer_4237 KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; SMART: CBS domain containing protein; Belongs to the SIS family. GutQ/KpsF subfamily. | UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.905 |
ACS21896.1 | lpxK | Vapar_5294 | Vapar_2641 | KEGG: rfr:Rfer_4237 KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; SMART: CBS domain containing protein; Belongs to the SIS family. GutQ/KpsF subfamily. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.905 |
fabZ | lpxA | Vapar_2610 | Vapar_2611 | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.995 |
fabZ | lpxB | Vapar_2610 | Vapar_2612 | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.911 |
fabZ | lpxC | Vapar_2610 | Vapar_0925 | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | UDP-3-0-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.941 |
fabZ | lpxD | Vapar_2610 | Vapar_2609 | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.982 |