close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACS18611.1Diguanylate phosphodiesterase; PFAM: EAL domain protein; SMART: EAL domain protein; KEGG: azo:azo0335 EAL-domain-containing protein. (248 aa)    
Predicted Functional Partners:
ACS22668.1
Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); KEGG: pfo:Pfl01_4551 diguanylate cyclase/phosphodiesterase; TIGRFAM: diguanylate cyclase; PAS sensor protein; PFAM: EAL domain protein; PAS fold-3 domain protein; GGDEF domain containing protein; response regulator receiver; PAS fold-4 domain protein; SMART: EAL domain protein; GGDEF domain containing protein; PAC repeat-containing protein.
 
 
 0.919
ACS22723.1
Diguanylate cyclase with PAS/PAC sensor; KEGG: rso:RS01984 hypothetical protein; TIGRFAM: diguanylate cyclase; PAS sensor protein; PFAM: GGDEF domain containing protein; PAS fold-3 domain protein; PAS fold domain protein; PAS fold-4 domain protein; histidine kinase HAMP region domain protein; SMART: GGDEF domain containing protein; PAC repeat-containing protein; histidine kinase HAMP region domain protein; PAS domain containing protein.
 
 
 0.907
ACS17370.1
KEGG: gbm:Gbem_0081 diguanylate cyclase with PAS/PAC sensor; TIGRFAM: diguanylate cyclase; PAS sensor protein; PFAM: GGDEF domain containing protein; Cache domain protein; PAS fold domain protein; PAS fold-4 domain protein; histidine kinase HAMP region domain protein; SMART: GGDEF domain containing protein; PAS domain containing protein.
 
 0.894
ACS18613.1
KEGG: lch:Lcho_2470 diguanylate cyclase with PAS/PAC sensor; TIGRFAM: diguanylate cyclase; PAS sensor protein; PFAM: GGDEF domain containing protein; Cache domain protein; PAS fold domain protein; PAS fold-4 domain protein; histidine kinase HAMP region domain protein; SMART: GGDEF domain containing protein; histidine kinase HAMP region domain protein; PAS domain containing protein.
 
 
 0.893
ACS22281.1
Diguanylate cyclase; KEGG: har:HEAR1734 GGDEF domain-containing protein; TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; SMART: GGDEF domain containing protein.
 
 
 0.857
ACS20933.1
Diguanylate cyclase; KEGG: har:HEAR1734 GGDEF domain-containing protein; TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; SMART: GGDEF domain containing protein.
 
 
 0.845
ACS21236.1
Transcriptional regulator, Fis family; PFAM: helix-turn-helix Fis-type; KEGG: pol:Bpro_1131 DNA-binding protein fis; Belongs to the transcriptional regulatory Fis family.
    
 
 0.718
ACS22586.1
KEGG: dac:Daci_5335 diguanylate cyclase; TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; SMART: GGDEF domain containing protein.
 
  
 0.657
ACS22670.1
KEGG: gme:Gmet_3085 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); TIGRFAM: diguanylate cyclase; PFAM: EAL domain protein; GGDEF domain containing protein; histidine kinase HAMP region domain protein; SMART: EAL domain protein; GGDEF domain containing protein; histidine kinase HAMP region domain protein.
 
  
0.651
flhD
Flagellar transcriptional activator; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family.
    
 
 0.638
Your Current Organism:
Variovorax paradoxus S110
NCBI taxonomy Id: 543728
Other names: V. paradoxus S110, Variovorax paradoxus str. S110, Variovorax paradoxus strain S110
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.