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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)    
Predicted Functional Partners:
ACS18996.1
TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: vei:Veis_1746 acetolactate synthase 3 regulatory subunit.
 
 
 0.999
ACS18995.1
TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; KEGG: ajs:Ajs_1769 acetolactate synthase 3 catalytic subunit.
 
 
 0.992
ilvD
PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: dac:Daci_2450 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.991
ACS19829.1
PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: bch:Bcen2424_6629 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.991
ACS18693.1
TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; KEGG: bpt:Bpet0027 acetolactate synthase large subunit.
 
 
 0.989
ilvD-2
KEGG: pol:Bpro_2052 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.989
ACS22180.1
PFAM: thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein TPP binding domain protein; KEGG: oan:Oant_4081 thiamine pyrophosphate protein central region; Belongs to the TPP enzyme family.
 
 
 0.986
ACS22824.1
PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: pol:Bpro_3810 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.982
ACS19785.1
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: dac:Daci_0959 hypothetical protein; Belongs to the TPP enzyme family.
 
 
 0.978
ACS22141.1
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: oan:Oant_1410 thiamine pyrophosphate protein domain protein TPP-binding; Belongs to the TPP enzyme family.
 
 
 0.977
Your Current Organism:
Variovorax paradoxus S110
NCBI taxonomy Id: 543728
Other names: V. paradoxus S110, Variovorax paradoxus str. S110, Variovorax paradoxus strain S110
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