guaA protein (Variovorax paradoxus S110) - STRING interaction network

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Score

guaA

GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (539 aa)

Predicted Functional Partners:

guaC

0.999

guaB

0.999

purL

0.989

argS

0.986

rplK

0.977

ACS20935.1

0.977

pyrG

0.975

gmk

0.972

purD

0.971

purA

0.969

Your Current Organism:

Variovorax paradoxus S110

NCBI taxonomy Id: 543728
Other names: V. paradoxus S110, Variovorax paradoxus str. S110, Variovorax paradoxus strain S110

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACS20935.1	gmk	Vapar_4324	Vapar_4329	Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.685
ACS20935.1	guaA	Vapar_4324	Vapar_2764	Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.	0.977
ACS20935.1	guaB	Vapar_4324	Vapar_2761	Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.948
ACS20935.1	guaC	Vapar_4324	Vapar_1534	Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.	0.462
ACS20935.1	purA	Vapar_4324	Vapar_2198	Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.654
argS	gmk	Vapar_0461	Vapar_4329	KEGG: rfr:Rfer_0773 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.606
argS	guaA	Vapar_0461	Vapar_2764	KEGG: rfr:Rfer_0773 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase.	GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.	0.986
argS	guaB	Vapar_0461	Vapar_2761	KEGG: rfr:Rfer_0773 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.409
argS	purL	Vapar_0461	Vapar_2940	KEGG: rfr:Rfer_0773 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase.	Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.	0.744
argS	pyrG	Vapar_0461	Vapar_3443	KEGG: rfr:Rfer_0773 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.891
argS	rplK	Vapar_0461	Vapar_0584	KEGG: rfr:Rfer_0773 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase.	Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	0.633
gmk	ACS20935.1	Vapar_4329	Vapar_4324	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.685
gmk	argS	Vapar_4329	Vapar_0461	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	KEGG: rfr:Rfer_0773 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase.	0.606
gmk	guaA	Vapar_4329	Vapar_2764	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.	0.972
gmk	guaB	Vapar_4329	Vapar_2761	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.589
gmk	guaC	Vapar_4329	Vapar_1534	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.	0.932
gmk	purA	Vapar_4329	Vapar_2198	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.537
gmk	purD	Vapar_4329	Vapar_2684	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	KEGG: ajs:Ajs_1899 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: phosphoribosylglycinamide synthetase; Belongs to the GARS family.	0.494
gmk	purL	Vapar_4329	Vapar_2940	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.	0.873
gmk	pyrG	Vapar_4329	Vapar_3443	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.579