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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACS19703.1Methylenetetrahydrofolate dehydrogenase (NADP(+)); PFAM: Methylene-tetrahydromethanopterin dehydrogenase; KEGG: mpt:Mpe_A2607 methylene tetrahydromethanopterin dehydrogenase/methylenetetrahydrofolate dehydrogenase, putative. (305 aa)    
Predicted Functional Partners:
mch
Methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT; Belongs to the MCH family.
 
  
 0.996
ACS19698.1
TIGRFAM: formaldehyde-activating enzyme; PFAM: Formaldehyde-activating enzyme (Fae); KEGG: mpt:Mpe_A2612 formaldehyde-activating enzyme.
 
  
 0.992
ACS19682.1
TIGRFAM: formaldehyde-activating enzyme; PFAM: Formaldehyde-activating enzyme (Fae); KEGG: mpt:Mpe_A2627 putative formaldehyde-activating enzyme.
 
  
 0.980
ACS19699.1
PFAM: triphosphoribosyl-dephospho-CoA protein; KEGG: mpt:Mpe_A2611 ATP:dephospho-CoA triphosphoribosyl transferase.
 
     0.948
ACS19700.1
TIGRFAM: alpha-L-glutamate ligase, RimK family; PFAM: RimK domain protein ATP-grasp; KEGG: lch:Lcho_3149 alpha-L-glutamate ligase; Belongs to the RimK family.
 
     0.948
ACS19702.1
PFAM: protein of unknown function DUF201; KEGG: mpt:Mpe_A2608 hypothetical protein.
 
     0.948
ACS19704.1
TIGRFAM: beta-ribofuranosylaminobenzene 5'-phosphate synthase family; PFAM: GHMP kinase; KEGG: lch:Lcho_3153 beta-ribofuranosylaminobenzene 5'-phosphate synthase.
 
     0.917
ACS17580.1
PFAM: glycine hydroxymethyltransferase; aminotransferase class I and II; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: sil:SPO3529 serine hydroxymethyltransferase.
    
 0.904
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
 0.904
ffsA
Formylmethanofuran/tetrahydromethanopterin N-formyltransferase; Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT); Belongs to the FTR family.
 
   
 0.811
Your Current Organism:
Variovorax paradoxus S110
NCBI taxonomy Id: 543728
Other names: V. paradoxus S110, Variovorax paradoxus str. S110, Variovorax paradoxus strain S110
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