Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ACS20196.1Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); KEGG: reh:H16_A1248 predicted signal transduction protein containingCHASE, PAS, GGDEF and EAL domains; TIGRFAM: diguanylate cyclase; PFAM: EAL domain protein; PAS fold-3 domain protein; CHASE domain protein; GGDEF domain containing protein; SMART: EAL domain protein; GGDEF domain containing protein. (1107 aa)    
Predicted Functional Partners:
ACS22670.1
KEGG: gme:Gmet_3085 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); TIGRFAM: diguanylate cyclase; PFAM: EAL domain protein; GGDEF domain containing protein; histidine kinase HAMP region domain protein; SMART: EAL domain protein; GGDEF domain containing protein; histidine kinase HAMP region domain protein.
 
 
0.827
ACS22723.1
Diguanylate cyclase with PAS/PAC sensor; KEGG: rso:RS01984 hypothetical protein; TIGRFAM: diguanylate cyclase; PAS sensor protein; PFAM: GGDEF domain containing protein; PAS fold-3 domain protein; PAS fold domain protein; PAS fold-4 domain protein; histidine kinase HAMP region domain protein; SMART: GGDEF domain containing protein; PAC repeat-containing protein; histidine kinase HAMP region domain protein; PAS domain containing protein.
 
 
0.821
ACS17370.1
KEGG: gbm:Gbem_0081 diguanylate cyclase with PAS/PAC sensor; TIGRFAM: diguanylate cyclase; PAS sensor protein; PFAM: GGDEF domain containing protein; Cache domain protein; PAS fold domain protein; PAS fold-4 domain protein; histidine kinase HAMP region domain protein; SMART: GGDEF domain containing protein; PAS domain containing protein.
 
 
0.765
ACS18613.1
KEGG: lch:Lcho_2470 diguanylate cyclase with PAS/PAC sensor; TIGRFAM: diguanylate cyclase; PAS sensor protein; PFAM: GGDEF domain containing protein; Cache domain protein; PAS fold domain protein; PAS fold-4 domain protein; histidine kinase HAMP region domain protein; SMART: GGDEF domain containing protein; histidine kinase HAMP region domain protein; PAS domain containing protein.
 
 
0.765
ACS22668.1
Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); KEGG: pfo:Pfl01_4551 diguanylate cyclase/phosphodiesterase; TIGRFAM: diguanylate cyclase; PAS sensor protein; PFAM: EAL domain protein; PAS fold-3 domain protein; GGDEF domain containing protein; response regulator receiver; PAS fold-4 domain protein; SMART: EAL domain protein; GGDEF domain containing protein; PAC repeat-containing protein.
 
 
0.746
ACS22172.1
KEGG: acr:Acry_0578 PAS/PAC sensor hybrid histidine kinase; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; GAF domain protein; response regulator receiver; PAS fold-4 domain protein; PAS fold domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; GAF domain protein; response regulator receiver; histidine kinase A domain protein; PAS domain containing protein.
 
 
 0.738
ACS17371.1
PAS/PAC sensor hybrid histidine kinase; KEGG: scl:sce0929 two-component hybrid sensor and regulator; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; response regulator receiver; PAS fold-4 domain protein; PAS fold domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; response regulator receiver; histidine kinase A domain protein; PAC repeat-containing protein; PAS domain containing protein.
 
 
 0.720
ACS22281.1
Diguanylate cyclase; KEGG: har:HEAR1734 GGDEF domain-containing protein; TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; SMART: GGDEF domain containing protein.
 
 
0.675
ACS17173.1
Histidine kinase; PFAM: ATP-binding region ATPase domain protein; response regulator receiver; histidine kinase HAMP region domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; response regulator receiver; histidine kinase A domain protein; histidine kinase HAMP region domain protein; KEGG: azo:azo3438 putative virulence regulator protein.
  
  
 0.639
ACS18611.1
Diguanylate phosphodiesterase; PFAM: EAL domain protein; SMART: EAL domain protein; KEGG: azo:azo0335 EAL-domain-containing protein.
 
  
0.613
Your Current Organism:
Variovorax paradoxus S110
NCBI taxonomy Id: 543728
Other names: V. paradoxus S110, Variovorax paradoxus str. S110, Variovorax paradoxus strain S110
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.