Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ureDUrease accessory protein UreD; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter. (276 aa)    
Predicted Functional Partners:
ureA
KEGG: pna:Pnap_0977 urease subunit gamma; TIGRFAM: urease, gamma subunit; PFAM: Urease gamma subunit region; Belongs to the urease gamma subunit family.
 
 
 0.987
ureF
Urease accessory protein UreF; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
 
 
 0.984
ureB
KEGG: pna:Pnap_0975 urease subunit beta; TIGRFAM: urease, beta subunit; PFAM: Urease beta subunit; Belongs to the urease beta subunit family.
 
 
 0.983
ureC
KEGG: aav:Aave_3529 urease subunit alpha; TIGRFAM: urease, alpha subunit; PFAM: amidohydrolase; Urease alpha-subunit domain protein; Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
 
 
 0.969
ureG
Urease accessory protein UreG; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
 
 
 0.957
ureE
UreE urease accessory domain protein; Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. Belongs to the UreE family.
 
   
 0.891
ACS20583.1
PFAM: NMT1/THI5 like domain protein; KEGG: dac:Daci_1136 NMT1/THI5-like domain-containing protein.
     
 0.700
ACS20623.1
KEGG: pna:Pnap_1000 ABC transporter related; TIGRFAM: urea ABC transporter, ATP-binding protein UrtD; PFAM: ABC transporter related; SMART: AAA ATPase.
 
   
 0.693
ACS20584.1
PFAM: CMP/dCMP deaminase zinc-binding; KEGG: aav:Aave_1083 CMP/dCMP deaminase, zinc-binding.
       0.664
ACS20624.1
TIGRFAM: urea ABC transporter, permease protein UrtC; PFAM: inner-membrane translocator; KEGG: pol:Bpro_1395 inner-membrane translocator; Belongs to the binding-protein-dependent transport system permease family.
 
   
 0.649
Your Current Organism:
Variovorax paradoxus S110
NCBI taxonomy Id: 543728
Other names: V. paradoxus S110, Variovorax paradoxus str. S110, Variovorax paradoxus strain S110
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.