| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACS17863.1 | ACS18060.1 | Vapar_1212 | Vapar_1409 | PFAM: peptidase S14 ClpP; KEGG: bpt:Bpet3891 ATP-dependent Clp protease proteolytic component. | KEGG: dac:Daci_1060 molecular chaperone, HSP70 class. | 0.608 |
| ACS17863.1 | ACS19854.1 | Vapar_1212 | Vapar_3236 | PFAM: peptidase S14 ClpP; KEGG: bpt:Bpet3891 ATP-dependent Clp protease proteolytic component. | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; SMART: heat shock protein DnaJ domain protein; KEGG: bav:BAV0873 curved DNA-binding protein. | 0.512 |
| ACS17863.1 | dnaJ | Vapar_1212 | Vapar_1711 | PFAM: peptidase S14 ClpP; KEGG: bpt:Bpet3891 ATP-dependent Clp protease proteolytic component. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.532 |
| ACS17863.1 | dnaK | Vapar_1212 | Vapar_1712 | PFAM: peptidase S14 ClpP; KEGG: bpt:Bpet3891 ATP-dependent Clp protease proteolytic component. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.624 |
| ACS17863.1 | groL | Vapar_1212 | Vapar_1118 | PFAM: peptidase S14 ClpP; KEGG: bpt:Bpet3891 ATP-dependent Clp protease proteolytic component. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.833 |
| ACS17863.1 | grpE | Vapar_1212 | Vapar_1713 | PFAM: peptidase S14 ClpP; KEGG: bpt:Bpet3891 ATP-dependent Clp protease proteolytic component. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.666 |
| ACS17863.1 | hrcA | Vapar_1212 | Vapar_4335 | PFAM: peptidase S14 ClpP; KEGG: bpt:Bpet3891 ATP-dependent Clp protease proteolytic component. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.824 |
| ACS17863.1 | hscA | Vapar_1212 | Vapar_2146 | PFAM: peptidase S14 ClpP; KEGG: bpt:Bpet3891 ATP-dependent Clp protease proteolytic component. | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. | 0.619 |
| ACS18060.1 | ACS17863.1 | Vapar_1409 | Vapar_1212 | KEGG: dac:Daci_1060 molecular chaperone, HSP70 class. | PFAM: peptidase S14 ClpP; KEGG: bpt:Bpet3891 ATP-dependent Clp protease proteolytic component. | 0.608 |
| ACS18060.1 | ACS19099.1 | Vapar_1409 | Vapar_2473 | KEGG: dac:Daci_1060 molecular chaperone, HSP70 class. | PFAM: peptidase S14 ClpP; KEGG: hap:HAPS_0606 Clp protease-like protein; Belongs to the peptidase S14 family. | 0.608 |
| ACS18060.1 | ACS19854.1 | Vapar_1409 | Vapar_3236 | KEGG: dac:Daci_1060 molecular chaperone, HSP70 class. | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; SMART: heat shock protein DnaJ domain protein; KEGG: bav:BAV0873 curved DNA-binding protein. | 0.971 |
| ACS18060.1 | clpP | Vapar_1409 | Vapar_2511 | KEGG: dac:Daci_1060 molecular chaperone, HSP70 class. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.608 |
| ACS18060.1 | dnaJ | Vapar_1409 | Vapar_1711 | KEGG: dac:Daci_1060 molecular chaperone, HSP70 class. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.976 |
| ACS18060.1 | groL | Vapar_1409 | Vapar_1118 | KEGG: dac:Daci_1060 molecular chaperone, HSP70 class. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.959 |
| ACS18060.1 | grpE | Vapar_1409 | Vapar_1713 | KEGG: dac:Daci_1060 molecular chaperone, HSP70 class. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.977 |
| ACS18060.1 | hrcA | Vapar_1409 | Vapar_4335 | KEGG: dac:Daci_1060 molecular chaperone, HSP70 class. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.899 |
| ACS19099.1 | ACS18060.1 | Vapar_2473 | Vapar_1409 | PFAM: peptidase S14 ClpP; KEGG: hap:HAPS_0606 Clp protease-like protein; Belongs to the peptidase S14 family. | KEGG: dac:Daci_1060 molecular chaperone, HSP70 class. | 0.608 |
| ACS19099.1 | ACS19854.1 | Vapar_2473 | Vapar_3236 | PFAM: peptidase S14 ClpP; KEGG: hap:HAPS_0606 Clp protease-like protein; Belongs to the peptidase S14 family. | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; SMART: heat shock protein DnaJ domain protein; KEGG: bav:BAV0873 curved DNA-binding protein. | 0.512 |
| ACS19099.1 | dnaJ | Vapar_2473 | Vapar_1711 | PFAM: peptidase S14 ClpP; KEGG: hap:HAPS_0606 Clp protease-like protein; Belongs to the peptidase S14 family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.532 |
| ACS19099.1 | dnaK | Vapar_2473 | Vapar_1712 | PFAM: peptidase S14 ClpP; KEGG: hap:HAPS_0606 Clp protease-like protein; Belongs to the peptidase S14 family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.624 |
STRING v12.5 is now available!
