node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS16830.1 | ACS16834.1 | Vapar_0167 | Vapar_0171 | PFAM: homocysteine S-methyltransferase; KEGG: pna:Pnap_0115 homocysteine S-methyltransferase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.999 |
ACS16830.1 | ACS18395.1 | Vapar_0167 | Vapar_1745 | PFAM: homocysteine S-methyltransferase; KEGG: pna:Pnap_0115 homocysteine S-methyltransferase. | PFAM: Methionine synthase vitamin-B12 independent; Cobalamin-independent synthase MetE domain protein; KEGG: pol:Bpro_3388 methionine synthase, vitamin-B12 independent. | 0.964 |
ACS16830.1 | ACS18534.1 | Vapar_0167 | Vapar_1884 | PFAM: homocysteine S-methyltransferase; KEGG: pna:Pnap_0115 homocysteine S-methyltransferase. | KEGG: dac:Daci_5774 cystathionine beta-lyase; TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. | 0.949 |
ACS16830.1 | ACS18838.1 | Vapar_0167 | Vapar_2203 | PFAM: homocysteine S-methyltransferase; KEGG: pna:Pnap_0115 homocysteine S-methyltransferase. | TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: dia:Dtpsy_1601 Cys/Met metabolism pyridoxal-phosphate-dependent protein. | 0.949 |
ACS16830.1 | ACS20590.1 | Vapar_0167 | Vapar_3976 | PFAM: homocysteine S-methyltransferase; KEGG: pna:Pnap_0115 homocysteine S-methyltransferase. | TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: vei:Veis_4134 cystathionine beta-lyase. | 0.949 |
ACS16830.1 | ACS21286.1 | Vapar_0167 | Vapar_4681 | PFAM: homocysteine S-methyltransferase; KEGG: pna:Pnap_0115 homocysteine S-methyltransferase. | KEGG: aav:Aave_4058 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.991 |
ACS16830.1 | ahcY | Vapar_0167 | Vapar_4683 | PFAM: homocysteine S-methyltransferase; KEGG: pna:Pnap_0115 homocysteine S-methyltransferase. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.944 |
ACS16830.1 | metE | Vapar_0167 | Vapar_3248 | PFAM: homocysteine S-methyltransferase; KEGG: pna:Pnap_0115 homocysteine S-methyltransferase. | 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.964 |
ACS16830.1 | metK | Vapar_0167 | Vapar_1126 | PFAM: homocysteine S-methyltransferase; KEGG: pna:Pnap_0115 homocysteine S-methyltransferase. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.944 |
ACS16830.1 | metZ | Vapar_0167 | Vapar_3758 | PFAM: homocysteine S-methyltransferase; KEGG: pna:Pnap_0115 homocysteine S-methyltransferase. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.949 |
ACS16834.1 | ACS16830.1 | Vapar_0171 | Vapar_0167 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: homocysteine S-methyltransferase; KEGG: pna:Pnap_0115 homocysteine S-methyltransferase. | 0.999 |
ACS16834.1 | ACS18395.1 | Vapar_0171 | Vapar_1745 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: Methionine synthase vitamin-B12 independent; Cobalamin-independent synthase MetE domain protein; KEGG: pol:Bpro_3388 methionine synthase, vitamin-B12 independent. | 0.926 |
ACS16834.1 | ACS18534.1 | Vapar_0171 | Vapar_1884 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | KEGG: dac:Daci_5774 cystathionine beta-lyase; TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. | 0.929 |
ACS16834.1 | ACS18838.1 | Vapar_0171 | Vapar_2203 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: dia:Dtpsy_1601 Cys/Met metabolism pyridoxal-phosphate-dependent protein. | 0.929 |
ACS16834.1 | ACS20590.1 | Vapar_0171 | Vapar_3976 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: vei:Veis_4134 cystathionine beta-lyase. | 0.929 |
ACS16834.1 | ACS21286.1 | Vapar_0171 | Vapar_4681 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | KEGG: aav:Aave_4058 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.992 |
ACS16834.1 | ahcY | Vapar_0171 | Vapar_4683 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.942 |
ACS16834.1 | metE | Vapar_0171 | Vapar_3248 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.926 |
ACS16834.1 | metK | Vapar_0171 | Vapar_1126 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.942 |
ACS16834.1 | metZ | Vapar_0171 | Vapar_3758 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.929 |