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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aceK(Isocitrate dehydrogenase (NADP(+))) kinase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (606 aa)    
Predicted Functional Partners:
ACS18519.1
TIGRFAM: isocitrate lyase; PFAM: isocitrate lyase and phosphorylmutase; KEGG: pol:Bpro_2101 isocitrate lyase.
 
  
 0.933
ACS19274.1
TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: pol:Bpro_2942 isocitrate dehydrogenase.
 
 
 
 0.914
ACS21339.1
Carbonate dehydratase; PFAM: carbonic anhydrase; KEGG: pol:Bpro_4189 carbonate dehydratase.
       0.816
ACS21337.1
KEGG: aav:Aave_4368 acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family.
  
    0.750
ACS21340.1
Transcriptional regulator, MerR family; PFAM: Transcription regulator MerR DNA binding; regulatory protein MerR; SMART: regulatory protein MerR; KEGG: pna:Pnap_0453 MerR family transcriptional regulator.
       0.689
glcB
Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.
  
  
 0.579
ACS21341.1
Cyclic nucleotide-binding protein; PFAM: beta-lactamase domain protein; KEGG: rfr:Rfer_3844 beta-lactamase-like.
       0.526
ACS21343.1
PFAM: pseudouridine synthase; KEGG: pol:Bpro_2906 pseudouridine synthase.
       0.473
ACS21342.1
PFAM: tyrosine protein kinase; leucine-rich repeat protein; SMART: serine/threonine protein kinase; tyrosine protein kinase; leucine-rich repeat-containing protein typical subtype; KEGG: bam:Bamb_4410 serine/threonine protein kinase.
       0.449
ACS21336.1
PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: bbt:BBta_1203 glutamate carboxypeptidase.
       0.426
Your Current Organism:
Variovorax paradoxus S110
NCBI taxonomy Id: 543728
Other names: V. paradoxus S110, Variovorax paradoxus str. S110, Variovorax paradoxus strain S110
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