node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKM06946.1 | AKM07324.1 | AM2010_868 | AM2010_1250 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | ATP phosphoribosyltransferase; Pfam:pfam13393 Histidyl-tRNA synthetase. | 0.960 |
AKM06946.1 | AKM08156.1 | AM2010_868 | AM2010_2096 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Fructose-1,6-bisphosphatase; Pfam:pfam00459 Inositol monophosphatase family. | 0.437 |
AKM06946.1 | hisA | AM2010_868 | AM2010_203 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Pfam:pfam00977 Histidine biosynthesis protein. | 0.999 |
AKM06946.1 | hisB | AM2010_868 | AM2010_201 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Pfam:pfam00475 Imidazoleglycerol-phosphate dehydratase. | 0.990 |
AKM06946.1 | hisC | AM2010_868 | AM2010_2592 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Pfam:pfam00155 Aminotransferase class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.980 |
AKM06946.1 | hisD | AM2010_868 | AM2010_1112 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.990 |
AKM06946.1 | hisE | AM2010_868 | AM2010_1730 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Pfam:pfam01503 Phosphoribosyl-ATP pyrophosphohydrolase. | 0.994 |
AKM06946.1 | hisF | AM2010_868 | AM2010_204 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.997 |
AKM06946.1 | hisG | AM2010_868 | AM2010_1111 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.986 |
AKM06946.1 | hisH | AM2010_868 | AM2010_202 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.990 |
AKM07324.1 | AKM06946.1 | AM2010_1250 | AM2010_868 | ATP phosphoribosyltransferase; Pfam:pfam13393 Histidyl-tRNA synthetase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | 0.960 |
AKM07324.1 | hisA | AM2010_1250 | AM2010_203 | ATP phosphoribosyltransferase; Pfam:pfam13393 Histidyl-tRNA synthetase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Pfam:pfam00977 Histidine biosynthesis protein. | 0.917 |
AKM07324.1 | hisB | AM2010_1250 | AM2010_201 | ATP phosphoribosyltransferase; Pfam:pfam13393 Histidyl-tRNA synthetase. | Pfam:pfam00475 Imidazoleglycerol-phosphate dehydratase. | 0.911 |
AKM07324.1 | hisC | AM2010_1250 | AM2010_2592 | ATP phosphoribosyltransferase; Pfam:pfam13393 Histidyl-tRNA synthetase. | Pfam:pfam00155 Aminotransferase class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.888 |
AKM07324.1 | hisD | AM2010_1250 | AM2010_1112 | ATP phosphoribosyltransferase; Pfam:pfam13393 Histidyl-tRNA synthetase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.910 |
AKM07324.1 | hisE | AM2010_1250 | AM2010_1730 | ATP phosphoribosyltransferase; Pfam:pfam13393 Histidyl-tRNA synthetase. | Pfam:pfam01503 Phosphoribosyl-ATP pyrophosphohydrolase. | 0.987 |
AKM07324.1 | hisF | AM2010_1250 | AM2010_204 | ATP phosphoribosyltransferase; Pfam:pfam13393 Histidyl-tRNA synthetase. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.909 |
AKM07324.1 | hisG | AM2010_1250 | AM2010_1111 | ATP phosphoribosyltransferase; Pfam:pfam13393 Histidyl-tRNA synthetase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.999 |
AKM07324.1 | hisH | AM2010_1250 | AM2010_202 | ATP phosphoribosyltransferase; Pfam:pfam13393 Histidyl-tRNA synthetase. | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.899 |
AKM08156.1 | AKM06946.1 | AM2010_2096 | AM2010_868 | Fructose-1,6-bisphosphatase; Pfam:pfam00459 Inositol monophosphatase family. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | 0.437 |