node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKM06882.1 | AKM07445.1 | AM2010_803 | AM2010_1373 | Pfam:pfam10369 Small subunit of acetolactate synthase. | Pfam:pfam14821 Threonine synthase N terminus. | 0.744 |
AKM06882.1 | AKM07722.1 | AM2010_803 | AM2010_1655 | Pfam:pfam10369 Small subunit of acetolactate synthase. | Hydroxymethylglutaryl-CoA lyase; Pfam:pfam00682 HMGL-like. | 0.785 |
AKM06882.1 | edd | AM2010_803 | AM2010_257 | Pfam:pfam10369 Small subunit of acetolactate synthase. | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 0.719 |
AKM06882.1 | ilvC | AM2010_803 | AM2010_802 | Pfam:pfam10369 Small subunit of acetolactate synthase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.998 |
AKM06882.1 | ilvD | AM2010_803 | AM2010_1349 | Pfam:pfam10369 Small subunit of acetolactate synthase. | Pfam:pfam00920 Dehydratase family; Belongs to the IlvD/Edd family. | 0.819 |
AKM06882.1 | leuA | AM2010_803 | AM2010_800 | Pfam:pfam10369 Small subunit of acetolactate synthase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.973 |
AKM06882.1 | leuB | AM2010_803 | AM2010_485 | Pfam:pfam10369 Small subunit of acetolactate synthase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.992 |
AKM06882.1 | leuC | AM2010_803 | AM2010_1585 | Pfam:pfam10369 Small subunit of acetolactate synthase. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.903 |
AKM06882.1 | leuD | AM2010_803 | AM2010_1588 | Pfam:pfam10369 Small subunit of acetolactate synthase. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.915 |
AKM07445.1 | AKM06882.1 | AM2010_1373 | AM2010_803 | Pfam:pfam14821 Threonine synthase N terminus. | Pfam:pfam10369 Small subunit of acetolactate synthase. | 0.744 |
AKM07445.1 | edd | AM2010_1373 | AM2010_257 | Pfam:pfam14821 Threonine synthase N terminus. | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 0.421 |
AKM07445.1 | ilvC | AM2010_1373 | AM2010_802 | Pfam:pfam14821 Threonine synthase N terminus. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.807 |
AKM07445.1 | ilvD | AM2010_1373 | AM2010_1349 | Pfam:pfam14821 Threonine synthase N terminus. | Pfam:pfam00920 Dehydratase family; Belongs to the IlvD/Edd family. | 0.427 |
AKM07445.1 | leuA | AM2010_1373 | AM2010_800 | Pfam:pfam14821 Threonine synthase N terminus. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.412 |
AKM07445.1 | leuB | AM2010_1373 | AM2010_485 | Pfam:pfam14821 Threonine synthase N terminus. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.624 |
AKM07445.1 | leuC | AM2010_1373 | AM2010_1585 | Pfam:pfam14821 Threonine synthase N terminus. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.606 |
AKM07445.1 | leuD | AM2010_1373 | AM2010_1588 | Pfam:pfam14821 Threonine synthase N terminus. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.905 |
AKM07656.1 | leuA | AM2010_1587 | AM2010_800 | Hypothetical protein. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.499 |
AKM07656.1 | leuB | AM2010_1587 | AM2010_485 | Hypothetical protein. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.499 |
AKM07656.1 | leuC | AM2010_1587 | AM2010_1585 | Hypothetical protein. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.841 |