STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sucDSuccinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (296 aa)    
Predicted Functional Partners:
sucC
Succinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.999
AKM07399.1
Succinate dehydrogenase iron-sulfur subunit; Pfam:pfam13085 2Fe-2S iron-sulfur cluster binding domain; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
 
 0.993
AKM07470.1
Succinate dehydrogenase flavoprotein subunit; Pfam:pfam00890 FAD binding domain; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
 
 0.992
AKM07472.1
Pfam:pfam01127 Succinate dehydrogenase/Fumarate reductase transmembrane subunit.
  
 
 0.989
AKM06624.1
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
  
 0.986
AKM06625.1
Alpha-ketoglutarate decarboxylase; Pfam:pfam02779 Transketolase, pyrimidine binding domain.
 
 
 0.961
AKM06664.1
2-oxoglutarate ferredoxin oxidoreductase alpha subunit; Pfam:pfam01855 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg.
  
 
 0.954
AKM07471.1
Pfam:pfam01127 Succinate dehydrogenase/Fumarate reductase transmembrane subunit.
  
 
 0.952
AKM07000.1
Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 0.949
AKM07082.1
Pfam:pfam01642 Methylmalonyl-CoA mutase.
    
 0.948
Your Current Organism:
Altererythrobacter marensis
NCBI taxonomy Id: 543877
Other names: A. marensis, Altererythrobacter marensis Seo and Lee 2010, Altererythrobacter sp. MSW-14, DSM 21428, KCTC 22370, strain MSW-14
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