node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
D521_0323 | D521_0733 | D521_0323 | D521_0733 | Thiamine pyrophosphate protein TPP binding domain protein; Belongs to the TPP enzyme family. | Acetolactate synthase, large subunit, biosynthetic type. | 0.926 |
D521_0323 | D521_0769 | D521_0323 | D521_0769 | Thiamine pyrophosphate protein TPP binding domain protein; Belongs to the TPP enzyme family. | Tartrate dehydrogenase. | 0.927 |
D521_0323 | D521_1488 | D521_0323 | D521_1488 | Thiamine pyrophosphate protein TPP binding domain protein; Belongs to the TPP enzyme family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.749 |
D521_0323 | ilvC | D521_0323 | D521_0735 | Thiamine pyrophosphate protein TPP binding domain protein; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.985 |
D521_0323 | ilvD | D521_0323 | D521_0544 | Thiamine pyrophosphate protein TPP binding domain protein; Belongs to the TPP enzyme family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.820 |
D521_0323 | ilvH | D521_0323 | D521_0734 | Thiamine pyrophosphate protein TPP binding domain protein; Belongs to the TPP enzyme family. | Acetolactate synthase, small subunit. | 0.995 |
D521_0323 | leuA | D521_0323 | D521_0738 | Thiamine pyrophosphate protein TPP binding domain protein; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.900 |
D521_0323 | leuB | D521_0323 | D521_1003 | Thiamine pyrophosphate protein TPP binding domain protein; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.940 |
D521_0323 | leuD | D521_0323 | D521_1004 | Thiamine pyrophosphate protein TPP binding domain protein; Belongs to the TPP enzyme family. | Isopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.402 |
D521_0733 | D521_0323 | D521_0733 | D521_0323 | Acetolactate synthase, large subunit, biosynthetic type. | Thiamine pyrophosphate protein TPP binding domain protein; Belongs to the TPP enzyme family. | 0.926 |
D521_0733 | D521_0769 | D521_0733 | D521_0769 | Acetolactate synthase, large subunit, biosynthetic type. | Tartrate dehydrogenase. | 0.927 |
D521_0733 | D521_1488 | D521_0733 | D521_1488 | Acetolactate synthase, large subunit, biosynthetic type. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.785 |
D521_0733 | ilvC | D521_0733 | D521_0735 | Acetolactate synthase, large subunit, biosynthetic type. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.995 |
D521_0733 | ilvD | D521_0733 | D521_0544 | Acetolactate synthase, large subunit, biosynthetic type. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.894 |
D521_0733 | ilvH | D521_0733 | D521_0734 | Acetolactate synthase, large subunit, biosynthetic type. | Acetolactate synthase, small subunit. | 0.999 |
D521_0733 | leuA | D521_0733 | D521_0738 | Acetolactate synthase, large subunit, biosynthetic type. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.931 |
D521_0733 | leuB | D521_0733 | D521_1003 | Acetolactate synthase, large subunit, biosynthetic type. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.945 |
D521_0733 | leuC | D521_0733 | D521_1006 | Acetolactate synthase, large subunit, biosynthetic type. | Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.473 |
D521_0733 | leuD | D521_0733 | D521_1004 | Acetolactate synthase, large subunit, biosynthetic type. | Isopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.501 |
D521_0769 | D521_0323 | D521_0769 | D521_0323 | Tartrate dehydrogenase. | Thiamine pyrophosphate protein TPP binding domain protein; Belongs to the TPP enzyme family. | 0.927 |