node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
D521_0733 | D521_1488 | D521_0733 | D521_1488 | Acetolactate synthase, large subunit, biosynthetic type. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.785 |
D521_0733 | ilvC | D521_0733 | D521_0735 | Acetolactate synthase, large subunit, biosynthetic type. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.995 |
D521_0733 | ilvD | D521_0733 | D521_0544 | Acetolactate synthase, large subunit, biosynthetic type. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.894 |
D521_0733 | ilvE | D521_0733 | D521_1813 | Acetolactate synthase, large subunit, biosynthetic type. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.457 |
D521_0733 | ilvH | D521_0733 | D521_0734 | Acetolactate synthase, large subunit, biosynthetic type. | Acetolactate synthase, small subunit. | 0.999 |
D521_0733 | leuA | D521_0733 | D521_0738 | Acetolactate synthase, large subunit, biosynthetic type. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.931 |
D521_0733 | leuC | D521_0733 | D521_1006 | Acetolactate synthase, large subunit, biosynthetic type. | Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.473 |
D521_0733 | leuD | D521_0733 | D521_1004 | Acetolactate synthase, large subunit, biosynthetic type. | Isopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.501 |
D521_0923 | acsA | D521_0923 | D521_0689 | Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.946 |
D521_0923 | leuA | D521_0923 | D521_0738 | Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.951 |
D521_1488 | D521_0733 | D521_1488 | D521_0733 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Acetolactate synthase, large subunit, biosynthetic type. | 0.785 |
D521_1488 | ilvC | D521_1488 | D521_0735 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.985 |
D521_1488 | ilvD | D521_1488 | D521_0544 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.921 |
D521_1488 | ilvE | D521_1488 | D521_1813 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.961 |
D521_1488 | ilvH | D521_1488 | D521_0734 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Acetolactate synthase, small subunit. | 0.659 |
D521_1488 | leuA | D521_1488 | D521_0738 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.976 |
D521_1488 | leuC | D521_1488 | D521_1006 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.818 |
D521_1488 | leuD | D521_1488 | D521_1004 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Isopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.728 |
acsA | D521_0923 | D521_0689 | D521_0923 | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.946 |
acsA | leuA | D521_0689 | D521_0738 | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.922 |