Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
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Fusion
Genes that are sometimes fused into single open reading frames.
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Textmining
Automated, unsupervised textmining - searching for proteins that are frequently mentioned together.
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Coexpression
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
D521_2029
Hypothetical protein. (121 aa)
Predicted Functional Partners:
D521_2030
Aspartyl/Asparaginyl beta-hydroxylase.
0.516
D521_2028
Histone family protein DNA-binding protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
0.512
Your Current Organism:
beta proteobacterium CB
NCBI taxonomy Id: 543913 Other names: b. proteobacterium CB
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
node1
node2
node1 annotation
node2 annotation
score
D521_2028
D521_2029
Histone family protein DNA-binding protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
Hypothetical protein.
0.512
D521_2029
D521_2028
Hypothetical protein.
Histone family protein DNA-binding protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
0.512
D521_2029
D521_2030
Hypothetical protein.
Aspartyl/Asparaginyl beta-hydroxylase.
0.516
D521_2030
D521_2029
Aspartyl/Asparaginyl beta-hydroxylase.
Hypothetical protein.
0.516
Network Stats
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Functional enrichments in your networkNote: some enrichments may be expected here (why?) disable highlightexplain columns
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: