node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GET3 | HCEG_01372 | F0U8A9 | F0U4R3 | ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] | Uncharacterized protein. | 0.960 |
GET3 | HCEG_03937 | F0U8A9 | F0UEJ2 | ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] | ER membrane protein complex subunit 3; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). Belongs to the EMC3 family. | 0.521 |
GET3 | HCEG_04141 | F0U8A9 | F0UFC2 | ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] | Protein transporter SEC61 alpha subunit. | 0.658 |
GET3 | HCEG_05503 | F0U8A9 | F0UHS9 | ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] | Translocon protein Sec61beta. | 0.820 |
GET3 | HCEG_07529 | F0U8A9 | F0UQY7 | ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] | DUF410 domain-containing protein. | 0.992 |
HCEG_00179 | HCEG_01372 | F0U7Z5 | F0U4R3 | Rnapii degradation factor def1. | Uncharacterized protein. | 0.520 |
HCEG_01372 | GET3 | F0U4R3 | F0U8A9 | Uncharacterized protein. | ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] | 0.960 |
HCEG_01372 | HCEG_00179 | F0U4R3 | F0U7Z5 | Uncharacterized protein. | Rnapii degradation factor def1. | 0.520 |
HCEG_01372 | HCEG_03937 | F0U4R3 | F0UEJ2 | Uncharacterized protein. | ER membrane protein complex subunit 3; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). Belongs to the EMC3 family. | 0.404 |
HCEG_01372 | HCEG_04141 | F0U4R3 | F0UFC2 | Uncharacterized protein. | Protein transporter SEC61 alpha subunit. | 0.412 |
HCEG_01372 | HCEG_05503 | F0U4R3 | F0UHS9 | Uncharacterized protein. | Translocon protein Sec61beta. | 0.670 |
HCEG_01372 | HCEG_07529 | F0U4R3 | F0UQY7 | Uncharacterized protein. | DUF410 domain-containing protein. | 0.553 |
HCEG_03937 | GET3 | F0UEJ2 | F0U8A9 | ER membrane protein complex subunit 3; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). Belongs to the EMC3 family. | ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] | 0.521 |
HCEG_03937 | HCEG_01372 | F0UEJ2 | F0U4R3 | ER membrane protein complex subunit 3; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). Belongs to the EMC3 family. | Uncharacterized protein. | 0.404 |
HCEG_03937 | HCEG_04141 | F0UEJ2 | F0UFC2 | ER membrane protein complex subunit 3; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). Belongs to the EMC3 family. | Protein transporter SEC61 alpha subunit. | 0.499 |
HCEG_04141 | GET3 | F0UFC2 | F0U8A9 | Protein transporter SEC61 alpha subunit. | ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] | 0.658 |
HCEG_04141 | HCEG_01372 | F0UFC2 | F0U4R3 | Protein transporter SEC61 alpha subunit. | Uncharacterized protein. | 0.412 |
HCEG_04141 | HCEG_03937 | F0UFC2 | F0UEJ2 | Protein transporter SEC61 alpha subunit. | ER membrane protein complex subunit 3; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). Belongs to the EMC3 family. | 0.499 |
HCEG_04141 | HCEG_05503 | F0UFC2 | F0UHS9 | Protein transporter SEC61 alpha subunit. | Translocon protein Sec61beta. | 0.998 |
HCEG_05503 | GET3 | F0UHS9 | F0U8A9 | Translocon protein Sec61beta. | ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] | 0.820 |