node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HCDG_00208 | HCDG_00351 | C6H4K7 | C6H530 | Pyruvate dehydrogenase complex component Pdx1. | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.926 |
HCDG_00208 | HCDG_01920 | C6H4K7 | C6H669 | Pyruvate dehydrogenase complex component Pdx1. | Malate synthase; Belongs to the malate synthase family. | 0.739 |
HCDG_00208 | HCDG_01926 | C6H4K7 | C6H675 | Pyruvate dehydrogenase complex component Pdx1. | Citrate synthase; Belongs to the citrate synthase family. | 0.879 |
HCDG_00208 | HCDG_04028 | C6H4K7 | C6HCU7 | Pyruvate dehydrogenase complex component Pdx1. | NAD-dependent methanol dehydrogenase. | 0.539 |
HCDG_00208 | HCDG_05056 | C6H4K7 | C6HGG5 | Pyruvate dehydrogenase complex component Pdx1. | Citrate synthase; Belongs to the citrate synthase family. | 0.879 |
HCDG_00208 | HCDG_05852 | C6H4K7 | C6HIG8 | Pyruvate dehydrogenase complex component Pdx1. | Succinyl-CoA ligase alpha-chain. | 0.910 |
HCDG_00208 | HCDG_06655 | C6H4K7 | C6HKC4 | Pyruvate dehydrogenase complex component Pdx1. | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.960 |
HCDG_00208 | HCDG_06679 | C6H4K7 | C6HKE8 | Pyruvate dehydrogenase complex component Pdx1. | Uncharacterized protein. | 0.671 |
HCDG_00208 | HCDG_08258 | C6H4K7 | C6HPX7 | Pyruvate dehydrogenase complex component Pdx1. | Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.910 |
HCDG_00208 | HCDG_09037 | C6H4K7 | C6HS56 | Pyruvate dehydrogenase complex component Pdx1. | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). | 0.887 |
HCDG_00351 | HCDG_00208 | C6H530 | C6H4K7 | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | Pyruvate dehydrogenase complex component Pdx1. | 0.926 |
HCDG_00351 | HCDG_01920 | C6H530 | C6H669 | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | Malate synthase; Belongs to the malate synthase family. | 0.844 |
HCDG_00351 | HCDG_01926 | C6H530 | C6H675 | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | Citrate synthase; Belongs to the citrate synthase family. | 0.928 |
HCDG_00351 | HCDG_04028 | C6H530 | C6HCU7 | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | NAD-dependent methanol dehydrogenase. | 0.484 |
HCDG_00351 | HCDG_05056 | C6H530 | C6HGG5 | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | Citrate synthase; Belongs to the citrate synthase family. | 0.928 |
HCDG_00351 | HCDG_05852 | C6H530 | C6HIG8 | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | Succinyl-CoA ligase alpha-chain. | 0.996 |
HCDG_00351 | HCDG_06655 | C6H530 | C6HKC4 | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.955 |
HCDG_00351 | HCDG_06679 | C6H530 | C6HKE8 | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | Uncharacterized protein. | 0.806 |
HCDG_00351 | HCDG_08258 | C6H530 | C6HPX7 | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.999 |
HCDG_00351 | HCDG_09037 | C6H530 | C6HS56 | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). | 0.988 |