| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| hom | ilvB | BN997_02185 | BN997_00919 | Homoserine dehydrogenase. | Acetolactate synthase large subunit. | 0.971 |
| hom | ilvC | BN997_02185 | BN997_00921 | Homoserine dehydrogenase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.973 |
| hom | ilvH | BN997_02185 | BN997_00920 | Homoserine dehydrogenase. | Acetolactate synthase small subunit. | 0.802 |
| hom | leuA | BN997_02185 | BN997_02975 | Homoserine dehydrogenase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.869 |
| hom | leuC | BN997_02185 | BN997_00923 | Homoserine dehydrogenase. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.942 |
| hom | leuD | BN997_02185 | BN997_00924 | Homoserine dehydrogenase. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.937 |
| hom | ttuC | BN997_02185 | BN997_00242 | Homoserine dehydrogenase. | Putative tartrate dehydrogenase/decarboxylase TtuC. | 0.887 |
| hom | ttuC-2 | BN997_02185 | BN997_01713 | Homoserine dehydrogenase. | Putative tartrate dehydrogenase/decarboxylase TtuC'. | 0.870 |
| icd | ttuC | BN997_04431 | BN997_00242 | Isocitrate dehydrogenase [NADP]. | Putative tartrate dehydrogenase/decarboxylase TtuC. | 0.768 |
| icd | ttuC-2 | BN997_04431 | BN997_01713 | Isocitrate dehydrogenase [NADP]. | Putative tartrate dehydrogenase/decarboxylase TtuC'. | 0.771 |
| ilvB | hom | BN997_00919 | BN997_02185 | Acetolactate synthase large subunit. | Homoserine dehydrogenase. | 0.971 |
| ilvB | ilvC | BN997_00919 | BN997_00921 | Acetolactate synthase large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.998 |
| ilvB | ilvH | BN997_00919 | BN997_00920 | Acetolactate synthase large subunit. | Acetolactate synthase small subunit. | 0.999 |
| ilvB | leuA | BN997_00919 | BN997_02975 | Acetolactate synthase large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.932 |
| ilvB | leuC | BN997_00919 | BN997_00923 | Acetolactate synthase large subunit. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.856 |
| ilvB | leuD | BN997_00919 | BN997_00924 | Acetolactate synthase large subunit. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.888 |
| ilvB | pflB | BN997_00919 | BN997_00076 | Acetolactate synthase large subunit. | Formate acetyltransferase. | 0.928 |
| ilvB | ttuC | BN997_00919 | BN997_00242 | Acetolactate synthase large subunit. | Putative tartrate dehydrogenase/decarboxylase TtuC. | 0.964 |
| ilvB | ttuC-2 | BN997_00919 | BN997_01713 | Acetolactate synthase large subunit. | Putative tartrate dehydrogenase/decarboxylase TtuC'. | 0.959 |
| ilvC | hom | BN997_00921 | BN997_02185 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Homoserine dehydrogenase. | 0.973 |