STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (342 aa)    
Predicted Functional Partners:
SDS33621.1
Acetolactate synthase, large subunit.
 
 
 0.999
SDS33709.1
Acetolactate synthase, small subunit.
 
 
 0.999
ilvD-2
Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.997
ilvD
Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.995
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
  
 0.990
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
  
 0.977
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
  
  
 0.935
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
  
  
 0.922
SDS55938.1
Glutamate synthase (NADH) large subunit.
  
  
 0.895
SDR91465.1
Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family.
 
 
 0.863
Your Current Organism:
Paraoerskovia marina
NCBI taxonomy Id: 545619
Other names: DSM 21750, DSM 22126 [[Koreibacter algae]], JCM 17443 [[Koreibacter algae]], KCTC 13436 [[Koreibacter algae]], Koreibacter algae, Koreibacter algae Lee and Lee 2010, Micrococcineae bacterium DSW-2, NBRC 104352, P. marina, Paraoerskovia marina Khan et al. 2009 emend. Schumann et al. 2013, strain CTT-37, strain DSW-2 [[Koreibacter algae]]
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