STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gyrA_2DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (848 aa)    
Predicted Functional Partners:
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
 0.996
AEF86690.1
DNA topoisomerase II (N- region) domain protein; Identified by match to protein family HMM PF00204; match to protein family HMM PF02518.
 
 0.983
AEF86121.1
Putative iron ABC transporter, solute-binding lipoprotein; Identified by match to protein family HMM PF01547.
       0.773
AEF86149.1
Sulfate/thiosulfate import ATP-binding protein CysA 2 (Sulfate-transporting ATPase 2); Identified by match to protein family HMM PF00005.
   
   0.770
metG
methionyl-tRNA synthetase (Methionine--tRNA ligase)(MetRS); Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
  
 0.769
AEF86923.1
Putative ABC transporter, permease protein; Identified by match to protein family HMM PF00528.
       0.757
AEF83636.1
Flagellar filament 34.5 kDa core protein (Class B); Component of the core of the flagella. Belongs to the bacterial flagellin family.
    
 
 0.756
flgF
Flagellar basal-body rod protein FlgF; Identified by match to protein family HMM PF00460; match to protein family HMM PF06429; match to protein family HMM TIGR02490; match to protein family HMM TIGR03506.
    
 
 0.752
AEF85105.1
Flagellar hook-basal body complex protein FliE.
    
 
 0.751
flgD
Flagellar hook capping protein; Identified by match to protein family HMM PF03963.
    
   0.739
Your Current Organism:
Treponema primitia ZAS2
NCBI taxonomy Id: 545694
Other names: T. primitia ZAS-2, Treponema primitia ZAS-2, Treponema primitia str. ZAS-2, Treponema primitia strain ZAS-2, Treponema sp. ZAS-2
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