STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tmkdTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (221 aa)    
Predicted Functional Partners:
dut
dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
  
 
 0.946
AEF85895.1
Vitamin B12-dependent ribonucleotide reductase (Ribonucleoside-diphosphate reductase NrdJ); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
  
 
 0.943
AEF84941.1
CMP/dCMP deaminase, zinc-binding protein; Identified by match to protein family HMM PF00383.
    
 0.929
thyX
Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
    
 0.929
AEF86846.1
Putative 5'-Nucleotidase domain protein; Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.
  
  0.921
AEF84201.1
Putative 5'-Nucleotidase domain protein; Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.
  
  0.921
ndk-2
Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
    
 0.919
AEF86474.1
Protein UshA; Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.
  
 
  0.913
surE
5'-nucleotidase SurE (Nucleoside 5'-monophosphatephosphohydrolase); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
  0.913
AEF83792.1
UshA protein; Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.
  
 
  0.913
Your Current Organism:
Treponema primitia ZAS2
NCBI taxonomy Id: 545694
Other names: T. primitia ZAS-2, Treponema primitia ZAS-2, Treponema primitia str. ZAS-2, Treponema primitia strain ZAS-2, Treponema sp. ZAS-2
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