AEF85038.1 protein (Treponema primitia ZAS2)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

AEF85038.1

Histidine biosynthesis bifunctional protein hisIE; Identified by match to protein family HMM PF00977; match to protein family HMM PF01502; match to protein family HMM PF01503; match to protein family HMM TIGR03188; Belongs to the HisA/HisF family. (438 aa)

Predicted Functional Partners:

hisD

0.999

hisH

0.999

AEF85012.1

0.999

hisC

0.998

hisF

0.998

hisB

0.998

AEF84311.1

0.992

AEF86387.1

0.986

thrH

0.986

AEF84522.1

0.954

Your Current Organism:

Treponema primitia ZAS2

NCBI taxonomy Id: 545694
Other names: T. primitia ZAS-2, Treponema primitia ZAS-2, Treponema primitia str. ZAS-2, Treponema primitia strain ZAS-2, Treponema sp. ZAS-2

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AEF84311.1	AEF84522.1	TREPR_0528	TREPR_2791	Threonine-phosphate decarboxylase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01140.	Bifunctional aspartokinase/homoserine dehydrogenase I; Identified by match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447; match to protein family HMM TIGR00657.	0.813
AEF84311.1	AEF85012.1	TREPR_0528	TREPR_3210	Threonine-phosphate decarboxylase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01140.	ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).	0.898
AEF84311.1	AEF85038.1	TREPR_0528	TREPR_3206	Threonine-phosphate decarboxylase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01140.	Histidine biosynthesis bifunctional protein hisIE; Identified by match to protein family HMM PF00977; match to protein family HMM PF01502; match to protein family HMM PF01503; match to protein family HMM TIGR03188; Belongs to the HisA/HisF family.	0.992
AEF84311.1	AEF86387.1	TREPR_0528	TREPR_2398	Threonine-phosphate decarboxylase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01140.	Conserved hypothetical protein; Identified by match to protein family HMM PF00483; match to protein family HMM TIGR01656; match to protein family HMM TIGR01662.	0.757
AEF84311.1	hisB	TREPR_0528	TREPR_3209	Threonine-phosphate decarboxylase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01140.	Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475.	0.984
AEF84311.1	hisD	TREPR_0528	TREPR_3204	Threonine-phosphate decarboxylase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01140.	Histidinol dehydrogenase (HDH); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.	0.960
AEF84311.1	hisF	TREPR_0528	TREPR_3207	Threonine-phosphate decarboxylase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01140.	Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.	0.905
AEF84311.1	hisH	TREPR_0528	TREPR_3208	Threonine-phosphate decarboxylase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01140.	Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	0.928
AEF84311.1	thrH	TREPR_0528	TREPR_3042	Threonine-phosphate decarboxylase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01140.	Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR02137.	0.698
AEF84522.1	AEF84311.1	TREPR_2791	TREPR_0528	Bifunctional aspartokinase/homoserine dehydrogenase I; Identified by match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447; match to protein family HMM TIGR00657.	Threonine-phosphate decarboxylase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01140.	0.813
AEF84522.1	AEF85012.1	TREPR_2791	TREPR_3210	Bifunctional aspartokinase/homoserine dehydrogenase I; Identified by match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447; match to protein family HMM TIGR00657.	ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).	0.886
AEF84522.1	AEF85038.1	TREPR_2791	TREPR_3206	Bifunctional aspartokinase/homoserine dehydrogenase I; Identified by match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447; match to protein family HMM TIGR00657.	Histidine biosynthesis bifunctional protein hisIE; Identified by match to protein family HMM PF00977; match to protein family HMM PF01502; match to protein family HMM PF01503; match to protein family HMM TIGR03188; Belongs to the HisA/HisF family.	0.954
AEF84522.1	hisB	TREPR_2791	TREPR_3209	Bifunctional aspartokinase/homoserine dehydrogenase I; Identified by match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447; match to protein family HMM TIGR00657.	Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475.	0.439
AEF84522.1	hisC	TREPR_2791	TREPR_3205	Bifunctional aspartokinase/homoserine dehydrogenase I; Identified by match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447; match to protein family HMM TIGR00657.	Histidinol-phosphate transaminase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	0.758
AEF84522.1	hisD	TREPR_2791	TREPR_3204	Bifunctional aspartokinase/homoserine dehydrogenase I; Identified by match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447; match to protein family HMM TIGR00657.	Histidinol dehydrogenase (HDH); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.	0.829
AEF84522.1	hisF	TREPR_2791	TREPR_3207	Bifunctional aspartokinase/homoserine dehydrogenase I; Identified by match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447; match to protein family HMM TIGR00657.	Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.	0.801
AEF84522.1	hisH	TREPR_2791	TREPR_3208	Bifunctional aspartokinase/homoserine dehydrogenase I; Identified by match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447; match to protein family HMM TIGR00657.	Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	0.429
AEF84522.1	thrH	TREPR_2791	TREPR_3042	Bifunctional aspartokinase/homoserine dehydrogenase I; Identified by match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447; match to protein family HMM TIGR00657.	Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR02137.	0.948
AEF85012.1	AEF84311.1	TREPR_3210	TREPR_0528	ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).	Threonine-phosphate decarboxylase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01140.	0.898
AEF85012.1	AEF84522.1	TREPR_3210	TREPR_2791	ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).	Bifunctional aspartokinase/homoserine dehydrogenase I; Identified by match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447; match to protein family HMM TIGR00657.	0.886

page 1 of 6

Server load: low (32%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2026

Credits

Access

Info

About