STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EEF69666.1Hypothetical protein; KEGG: rru:Rru_A1752 1.2e-15 excinuclease ABC, A subunit K03701; Psort location: Cytoplasmic, score: 8.87. (143 aa)    
Predicted Functional Partners:
EEF69665.1
KEGG: rru:Rru_A1752 2.9e-102 excinuclease ABC, A subunit K03701; Psort location: Cytoplasmic, score: 8.87.
     0.994
EEF69664.1
Hypothetical protein; KEGG: rru:Rru_A1752 1.8e-42 excinuclease ABC, A subunit K03701; Psort location: CytoplasmicMembrane, score: 9.49.
     0.993
EEF69618.1
KEGG: rru:Rru_A1752 6.6e-96 excinuclease ABC, A subunit K03701; Psort location: Cytoplasmic, score: 8.87.
     0.987
uvrB
Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
 
 
 0.977
pcrA
KEGG: chy:CHY_1099 1.6e-133 pcrA; ATP-dependent DNA helicase PcrA K03657; Psort location: Cytoplasmic, score: 8.87.
 
 
 0.824
uvrC
Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
 
 
 0.812
hprK
HPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable car [...]
     
 0.794
trxB
KEGG: bcl:ABC3038 8.2e-82 trxB; thioredoxin reductase K00384; Psort location: Cytoplasmic, score: 9.98.
     
 0.792
lgt
Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family.
     
 0.791
mfd
Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.
   
 
 0.789
Your Current Organism:
Holdemania filiformis
NCBI taxonomy Id: 545696
Other names: H. filiformis DSM 12042, Holdemania filiformis DSM 12042, Holdemania filiformis str. DSM 12042, Holdemania filiformis strain DSM 12042
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.