Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
EEF68967.1Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (348 aa)    
Predicted Functional Partners:
EEF68969.1
Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
 0.999
EEF69258.1
KEGG: mmo:MMOB0160 1.2e-85 nrdA; ribonucleotide-diphosphate reductase alpha subunit K00524; Psort location: Cytoplasmic, score: 8.87.
 
 0.989
EEF69257.1
Ribonucleotide reductase, barrel domain protein; KEGG: mmo:MMOB0160 2.7e-154 nrdA; ribonucleotide-diphosphate reductase alpha subunit K00524; Psort location: Cytoplasmic, score: 8.87.
  
 0.988
EEF67208.1
Glutaredoxin; KEGG: tte:TTE1850 1.3e-88 nrdD; oxygen-sensitive ribonucleoside-triphosphate reductase K00527.
  
 
 0.936
EEF67120.1
ATP cone domain protein; KEGG: tde:TDE1331 1.2e-135 nrdD; anaerobic ribonucleoside triphosphate reductase K00527; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.865
nrdD
KEGG: pac:PPA2137 4.7e-221 anaerobic ribonucleoside triphosphate reductase K00527; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.865
yjjI
Glycine radical enzyme, YjjI family; KEGG: cya:CYA_0477 0.00076 pflB; formate acetyltransferase K00656; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.854
tmk
dTMP kinase; KEGG: gka:GK0024 3.6e-40 thymidylate kinase K00943; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.837
cmk
Cytidylate kinase; KEGG: bsu:BG11004 3.8e-52 cmk, jofC, ypfC; cytidylate kinase K00945; Psort location: Cytoplasmic, score: 8.87.
    
 0.830
dut
dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
  
 
 0.821
Your Current Organism:
Holdemania filiformis
NCBI taxonomy Id: 545696
Other names: H. filiformis DSM 12042, Holdemania filiformis DSM 12042, Holdemania filiformis str. DSM 12042, Holdemania filiformis strain DSM 12042
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.