STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrF-2Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (235 aa)    
Predicted Functional Partners:
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
 
 0.999
pyrD
Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate.
 
 
 0.996
EEF68175.1
Oxidoreductase NAD-binding domain protein; KEGG: bcl:ABC2332 9.0e-44 pyrDII; dihydroorotate dehydrogenase electron transfer subunit K02823; Psort location: Cytoplasmic, score: 9.06.
 
 
 0.993
pyrR
Bifunctional protein PyrR; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
  
 
 0.985
pyrB
KEGG: gka:GK1149 5.6e-90 pyrB; aspartate carbamoyltransferase K00609; Psort location: Cytoplasmic, score: 9.98; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 
  
 0.977
pyrC
Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 
  
 0.972
upp
Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
  
 
 0.962
carB-2
Carbamoyl-phosphate synthetase, large subunit, oligomerization domain protein; KEGG: bca:BCE_3931 3.1e-217 carB; carbamoyl-phosphate synthase, large subunit K01955; Psort location: Cytoplasmic, score: 9.98; Belongs to the CarB family.
  
  
 0.951
carA
KEGG: gka:GK1151 1.2e-96 carbamoyl-phosphate synthase(glutamine-hydrolyzing) small chain K01956; Psort location: Cytoplasmic, score: 8.87; Belongs to the CarA family.
  
  
 0.948
pyrH
UMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
  
 
 0.944
Your Current Organism:
Holdemania filiformis
NCBI taxonomy Id: 545696
Other names: H. filiformis DSM 12042, Holdemania filiformis DSM 12042, Holdemania filiformis str. DSM 12042, Holdemania filiformis strain DSM 12042
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