EEF67435.1 protein (Holdemania filiformis) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

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[Homology]

Score

EEF67435.1

Toxin-antitoxin system, antitoxin component, Xre family; Psort location: Cytoplasmic, score: 8.87. (125 aa)

Predicted Functional Partners:

EEF68206.1

0.778

EEF66134.1

0.771

EEF69805.1

0.766

EEF69020.1

0.766

nifJ

0.757

EEF68653.1

0.754

EEF65946.1

0.754

nadE

0.751

EEF67436.1

0.710

EEF66173.1

0.678

Your Current Organism:

Holdemania filiformis

NCBI taxonomy Id: 545696
Other names: H. filiformis DSM 12042, Holdemania filiformis DSM 12042, Holdemania filiformis str. DSM 12042, Holdemania filiformis strain DSM 12042

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EEF65946.1	EEF66173.1	HOLDEFILI_03949	HOLDEFILI_03695	Hypothetical protein; Psort location: Cytoplasmic, score: 8.87.	KEGG: cyb:CYB_1515 4.6e-15 tetratricopeptide repeat/protein kinase domain protein K08884; Psort location: Cytoplasmic, score: 8.87.	0.930
EEF65946.1	EEF67435.1	HOLDEFILI_03949	HOLDEFILI_02451	Hypothetical protein; Psort location: Cytoplasmic, score: 8.87.	Toxin-antitoxin system, antitoxin component, Xre family; Psort location: Cytoplasmic, score: 8.87.	0.754
EEF66134.1	EEF67435.1	HOLDEFILI_03704	HOLDEFILI_02451	Competence/damage-inducible domain protein CinA; Belongs to the CinA family.	Toxin-antitoxin system, antitoxin component, Xre family; Psort location: Cytoplasmic, score: 8.87.	0.771
EEF66134.1	nadE	HOLDEFILI_03704	HOLDEFILI_03271	Competence/damage-inducible domain protein CinA; Belongs to the CinA family.	NAD+ synthase; KEGG: tte:TTE0640 6.1e-61 nadE; NAD synthase K01950; Psort location: Cytoplasmic, score: 8.87; Belongs to the NAD synthetase family.	0.967
EEF66134.1	nifJ	HOLDEFILI_03704	HOLDEFILI_01711	Competence/damage-inducible domain protein CinA; Belongs to the CinA family.	KEGG: fnu:FN1170 0. pyruvate-flavodoxin oxidoreductase K03737.	0.595
EEF66173.1	EEF65946.1	HOLDEFILI_03695	HOLDEFILI_03949	KEGG: cyb:CYB_1515 4.6e-15 tetratricopeptide repeat/protein kinase domain protein K08884; Psort location: Cytoplasmic, score: 8.87.	Hypothetical protein; Psort location: Cytoplasmic, score: 8.87.	0.930
EEF66173.1	EEF67435.1	HOLDEFILI_03695	HOLDEFILI_02451	KEGG: cyb:CYB_1515 4.6e-15 tetratricopeptide repeat/protein kinase domain protein K08884; Psort location: Cytoplasmic, score: 8.87.	Toxin-antitoxin system, antitoxin component, Xre family; Psort location: Cytoplasmic, score: 8.87.	0.678
EEF66173.1	EEF68653.1	HOLDEFILI_03695	HOLDEFILI_01174	KEGG: cyb:CYB_1515 4.6e-15 tetratricopeptide repeat/protein kinase domain protein K08884; Psort location: Cytoplasmic, score: 8.87.	Hypothetical protein.	0.930
EEF66173.1	nadE	HOLDEFILI_03695	HOLDEFILI_03271	KEGG: cyb:CYB_1515 4.6e-15 tetratricopeptide repeat/protein kinase domain protein K08884; Psort location: Cytoplasmic, score: 8.87.	NAD+ synthase; KEGG: tte:TTE0640 6.1e-61 nadE; NAD synthase K01950; Psort location: Cytoplasmic, score: 8.87; Belongs to the NAD synthetase family.	0.573
EEF66173.1	nifJ	HOLDEFILI_03695	HOLDEFILI_01711	KEGG: cyb:CYB_1515 4.6e-15 tetratricopeptide repeat/protein kinase domain protein K08884; Psort location: Cytoplasmic, score: 8.87.	KEGG: fnu:FN1170 0. pyruvate-flavodoxin oxidoreductase K03737.	0.856
EEF67435.1	EEF65946.1	HOLDEFILI_02451	HOLDEFILI_03949	Toxin-antitoxin system, antitoxin component, Xre family; Psort location: Cytoplasmic, score: 8.87.	Hypothetical protein; Psort location: Cytoplasmic, score: 8.87.	0.754
EEF67435.1	EEF66134.1	HOLDEFILI_02451	HOLDEFILI_03704	Toxin-antitoxin system, antitoxin component, Xre family; Psort location: Cytoplasmic, score: 8.87.	Competence/damage-inducible domain protein CinA; Belongs to the CinA family.	0.771
EEF67435.1	EEF66173.1	HOLDEFILI_02451	HOLDEFILI_03695	Toxin-antitoxin system, antitoxin component, Xre family; Psort location: Cytoplasmic, score: 8.87.	KEGG: cyb:CYB_1515 4.6e-15 tetratricopeptide repeat/protein kinase domain protein K08884; Psort location: Cytoplasmic, score: 8.87.	0.678
EEF67435.1	EEF67436.1	HOLDEFILI_02451	HOLDEFILI_02452	Toxin-antitoxin system, antitoxin component, Xre family; Psort location: Cytoplasmic, score: 8.87.	Putative toxin-antitoxin system, toxin component; Psort location: Cytoplasmic, score: 8.87.	0.710
EEF67435.1	EEF68206.1	HOLDEFILI_02451	HOLDEFILI_01627	Toxin-antitoxin system, antitoxin component, Xre family; Psort location: Cytoplasmic, score: 8.87.	Hypothetical protein.	0.778
EEF67435.1	EEF68653.1	HOLDEFILI_02451	HOLDEFILI_01174	Toxin-antitoxin system, antitoxin component, Xre family; Psort location: Cytoplasmic, score: 8.87.	Hypothetical protein.	0.754
EEF67435.1	EEF69020.1	HOLDEFILI_02451	HOLDEFILI_00800	Toxin-antitoxin system, antitoxin component, Xre family; Psort location: Cytoplasmic, score: 8.87.	Hypothetical protein; Psort location: Cytoplasmic, score: 8.87.	0.766
EEF67435.1	EEF69805.1	HOLDEFILI_02451	HOLDEFILI_00020	Toxin-antitoxin system, antitoxin component, Xre family; Psort location: Cytoplasmic, score: 8.87.	Hypothetical protein; Psort location: Cytoplasmic, score: 8.87.	0.766
EEF67435.1	nadE	HOLDEFILI_02451	HOLDEFILI_03271	Toxin-antitoxin system, antitoxin component, Xre family; Psort location: Cytoplasmic, score: 8.87.	NAD+ synthase; KEGG: tte:TTE0640 6.1e-61 nadE; NAD synthase K01950; Psort location: Cytoplasmic, score: 8.87; Belongs to the NAD synthetase family.	0.751
EEF67435.1	nifJ	HOLDEFILI_02451	HOLDEFILI_01711	Toxin-antitoxin system, antitoxin component, Xre family; Psort location: Cytoplasmic, score: 8.87.	KEGG: fnu:FN1170 0. pyruvate-flavodoxin oxidoreductase K03737.	0.757

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

17

average node degree:

3.09

avg. local clustering coefficient:

0.893

expected number of edges:

10

PPI enrichment p-value:

0.0337

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005223

Intracellular cGMP-activated cation channel activity

2 of 7

2.68

1.1

0.0101

GO:0005222

Intracellular cAMP-activated cation channel activity

2 of 9

2.57

1.09

0.0101

GO:0030553

cGMP binding

2 of 16

2.32

1.05

0.0117

GO:0015106

Bicarbonate transmembrane transporter activity

2 of 19

2.25

0.99

0.0146

GO:0099094

Ligand-gated cation channel activity

3 of 109

1.67

0.96

0.0109

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017071

Intracellular cyclic nucleotide activated cation channel complex

2 of 5

2.83

1.14

0.0088

GO:0036126

Sperm flagellum

3 of 98

1.71

0.9

0.0164

GO:0097225

Sperm midpiece

2 of 29

2.07

0.72

0.0459

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:24164424

(2013) Cyclic nucleotide-gated channel subunit glycosylation regulates matrix metalloproteinase-dependent changes in channel gating.

5 of 14

2.78

4.63

2.08e-09

PMID:33362798

(2020) Innovation in Nucleotide-Binding Oligomerization-Like Receptor and Toll-Like Receptor Sensing Drives the Major Histocompatibility Complex-II Free Atlantic Cod Immune System.

4 of 13

2.72

3.35

5.66e-07

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:19067

Mixed, incl. Bicarbonate transporters, and Ral GTPase-activating protein subunit alpha/beta, N-terminal domain

3 of 17

2.47

1.71

0.00069

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 11007

0.23

0.22

0.0282

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0017071

Intracellular cyclic nucleotide activated cation channel complex

2 of 5

2.83

1.09

0.0106

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0406

Ion transport

4 of 286

1.37

0.97

0.0051

KW-0813

Transport

5 of 615

1.14

0.83

0.0051

KW-0407

Ion channel

3 of 198

1.41

0.77

0.0207

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000595

Cyclic nucleotide-binding domain

3 of 26

2.29

1.34

0.0032

IPR018490

Cyclic nucleotide-binding domain superfamily

3 of 29

2.24

1.33

0.0032

IPR014710

RmlC-like jelly roll fold

3 of 37

2.14

1.31

0.0032

IPR032406

Cyclic nucleotide-gated channel, C-terminal leucine zipper domain

2 of 4

2.93

1.2

0.0069

IPR018488

Cyclic nucleotide-binding, conserved site

2 of 13

2.42

0.82

0.0319

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00100

Cyclic nucleotide-monophosphate binding domain

3 of 26

2.29

1.78

0.00042

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