STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (677 aa)    
Predicted Functional Partners:
nifJ
KEGG: fnu:FN1170 0. pyruvate-flavodoxin oxidoreductase K03737.
  
   0.999
recQ
KEGG: cpf:CPF_0327 2.9e-148 recQ; ATP-dependent DNA helicase RecQ K03654; Psort location: Cytoplasmic, score: 8.87.
  
 0.997
leuS
leucine--tRNA ligase; KEGG: gka:GK2842 2.1e-296 leuS; leucyl-tRNA synthetase K01869; Psort location: Cytoplasmic, score: 9.98; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
 
 0.993
EEF69463.1
KEGG: shn:Shewana3_3590 1.9e-18 single-strand binding protein K00655.
  
 
 0.969
EEF66117.1
KEGG: shn:Shewana3_3590 4.9e-09 single-strand binding protein K00655; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.969
EEF66087.1
Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-binding domain protein; KEGG: hpj:jhp1037 2.0e-48 porA; pyruvate ferredoxin oxidoreductase, alpha subunit K00169; Psort location: Cytoplasmic, score: 8.87.
  
   0.969
EEF66068.1
Hypothetical protein; KEGG: mja:MJ0266 1.4e-47 porB; pyruvate ferredoxin oxidoreductase, beta subunit K00170; Psort location: Cytoplasmic, score: 8.87.
  
   0.969
rpoC
DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
 
 
 0.962
polA
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
 0.958
rpoA
DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.954
Your Current Organism:
Holdemania filiformis
NCBI taxonomy Id: 545696
Other names: H. filiformis DSM 12042, Holdemania filiformis DSM 12042, Holdemania filiformis str. DSM 12042, Holdemania filiformis strain DSM 12042
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.