STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EEF66423.1Beta-eliminating lyase; KEGG: tte:TTE0267 8.3e-89 gly1; Threonine aldolase K01620; Psort location: Cytoplasmic, score: 8.87. (351 aa)    
Predicted Functional Partners:
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
   
 0.880
thrC
Threonine synthase; KEGG: blo:BL1036 3.8e-107 thrC; threonine synthase K01733; Psort location: Cytoplasmic, score: 8.87.
  
 0.834
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.
   
 0.790
EEF69283.1
Putative diaminopropionate ammonia-lyase; KEGG: ppr:PBPRA1993 6.6e-80 putative threonine dehydratase; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.781
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
    
 0.779
EEF66424.1
Putative phage prohead protease, HK97 family; KEGG: bce:BC1828 1.2e-82 Xaa-Pro aminopeptidase K01262; Psort location: Cytoplasmic, score: 8.87.
       0.778
kbl
Glycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
  
 
 0.773
EEF66425.1
Peptidase, S9A/B/C family, catalytic domain protein; KEGG: fnu:FN1128 4.2e-156 acylamino-acid-releasing enzyme K01303.
       0.773
gcvPB
Putative glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily.
    
 0.759
gcvPA
Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
    
 0.758
Your Current Organism:
Holdemania filiformis
NCBI taxonomy Id: 545696
Other names: H. filiformis DSM 12042, Holdemania filiformis DSM 12042, Holdemania filiformis str. DSM 12042, Holdemania filiformis strain DSM 12042
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.