STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
purBKEGG: gka:GK0259 6.3e-162 adenylosuccinate lyase K01756; Psort location: Cytoplasmic, score: 8.87. (422 aa)    
Predicted Functional Partners:
purC-2
KEGG: cpf:CPF_0673 2.4e-82 purC; phosphoribosylaminoimidazole-succinocarboxamide synthase K01923; Psort location: Cytoplasmic, score: 8.87; Belongs to the SAICAR synthetase family.
 0.999
purE
Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
 0.998
purA
Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 0.998
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
 
 
 0.996
EEF66581.1
KEGG: fnu:FN0990 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 8.87.
  
  
 0.995
purD
KEGG: btl:BALH_0293 4.1e-126 purD; phosphoribosylamine--glycine ligase K01945; Psort location: Cytoplasmic, score: 8.87; Belongs to the GARS family.
  
 0.995
purC
KEGG: sat:SYN_00107 1.9e-75 phosphoribosylaminoimidazole-succinocarboxamide synthase K01923; Psort location: Cytoplasmic, score: 8.87; Belongs to the SAICAR synthetase family.
  
 0.991
EEF69223.1
AICARFT/IMPCHase bienzyme; KEGG: xtr:448061 1.4e-118 atic; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase K00602:K01492; Psort location: Cytoplasmic, score: 8.87.
  
 0.990
purM
KEGG: lwe:lwe1785 3.0e-116 purM; phosphoribosylformylglycinamidine cyclo-ligase K01933; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.988
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
  
 0.986
Your Current Organism:
Holdemania filiformis
NCBI taxonomy Id: 545696
Other names: H. filiformis DSM 12042, Holdemania filiformis DSM 12042, Holdemania filiformis str. DSM 12042, Holdemania filiformis strain DSM 12042
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.