| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EKY22381.1 | EKY26247.1 | HMPREF0216_03269 | HMPREF0216_02029 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | 0.400 |
| EKY22381.1 | EKY28426.1 | HMPREF0216_03269 | HMPREF0216_00777 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Class II glutamine amidotransferase. | 0.531 |
| EKY22381.1 | guaA | HMPREF0216_03269 | HMPREF0216_03257 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.943 |
| EKY22381.1 | murD | HMPREF0216_03269 | HMPREF0216_02734 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.454 |
| EKY22381.1 | murI | HMPREF0216_03269 | HMPREF0216_00033 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.942 |
| EKY26247.1 | EKY22381.1 | HMPREF0216_02029 | HMPREF0216_03269 | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.400 |
| EKY26247.1 | EKY28426.1 | HMPREF0216_02029 | HMPREF0216_00777 | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | Class II glutamine amidotransferase. | 0.891 |
| EKY26247.1 | EKY29456.1 | HMPREF0216_02029 | HMPREF0216_00221 | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | Glu/Leu/Phe/Val dehydrogenase, dimerization domain protein; KEGG: cbk:CLL_A0779 2.7e-190 gluD; glutamate dehydrogenase K00262; Psort location: Cytoplasmic, score: 9.97; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.867 |
| EKY26247.1 | guaA | HMPREF0216_02029 | HMPREF0216_03257 | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.998 |
| EKY26247.1 | murD | HMPREF0216_02029 | HMPREF0216_02734 | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.818 |
| EKY26247.1 | murI | HMPREF0216_02029 | HMPREF0216_00033 | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.829 |
| EKY28426.1 | EKY22381.1 | HMPREF0216_00777 | HMPREF0216_03269 | Class II glutamine amidotransferase. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.531 |
| EKY28426.1 | EKY26247.1 | HMPREF0216_00777 | HMPREF0216_02029 | Class II glutamine amidotransferase. | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | 0.891 |
| EKY28426.1 | EKY29456.1 | HMPREF0216_00777 | HMPREF0216_00221 | Class II glutamine amidotransferase. | Glu/Leu/Phe/Val dehydrogenase, dimerization domain protein; KEGG: cbk:CLL_A0779 2.7e-190 gluD; glutamate dehydrogenase K00262; Psort location: Cytoplasmic, score: 9.97; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.999 |
| EKY28426.1 | glsA | HMPREF0216_00777 | HMPREF0216_02184 | Class II glutamine amidotransferase. | Glutaminase A; KEGG: cpr:CPR_1963 6.8e-107 glutaminase K01425; Psort location: Cytoplasmic, score: 7.50; Belongs to the glutaminase family. | 0.929 |
| EKY28426.1 | guaA | HMPREF0216_00777 | HMPREF0216_03257 | Class II glutamine amidotransferase. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.974 |
| EKY28426.1 | murD | HMPREF0216_00777 | HMPREF0216_02734 | Class II glutamine amidotransferase. | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.538 |
| EKY28426.1 | murI | HMPREF0216_00777 | HMPREF0216_00033 | Class II glutamine amidotransferase. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.677 |
| EKY29456.1 | EKY26247.1 | HMPREF0216_00221 | HMPREF0216_02029 | Glu/Leu/Phe/Val dehydrogenase, dimerization domain protein; KEGG: cbk:CLL_A0779 2.7e-190 gluD; glutamate dehydrogenase K00262; Psort location: Cytoplasmic, score: 9.97; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | 0.867 |
| EKY29456.1 | EKY28426.1 | HMPREF0216_00221 | HMPREF0216_00777 | Glu/Leu/Phe/Val dehydrogenase, dimerization domain protein; KEGG: cbk:CLL_A0779 2.7e-190 gluD; glutamate dehydrogenase K00262; Psort location: Cytoplasmic, score: 9.97; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Class II glutamine amidotransferase. | 0.999 |