| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EKY22381.1 | EKY26247.1 | HMPREF0216_03269 | HMPREF0216_02029 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | 0.697 |
| EKY22381.1 | EKY27430.1 | HMPREF0216_03269 | HMPREF0216_01379 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamine synthetase, beta-grasp domain protein; KEGG: cth:Cthe_0202 9.2e-158 L-glutamine synthetase K01915; Psort location: Cytoplasmic, score: 9.97. | 0.477 |
| EKY22381.1 | EKY28426.1 | HMPREF0216_03269 | HMPREF0216_00777 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Class II glutamine amidotransferase. | 0.594 |
| EKY22381.1 | EKY29456.1 | HMPREF0216_03269 | HMPREF0216_00221 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glu/Leu/Phe/Val dehydrogenase, dimerization domain protein; KEGG: cbk:CLL_A0779 2.7e-190 gluD; glutamate dehydrogenase K00262; Psort location: Cytoplasmic, score: 9.97; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.515 |
| EKY22381.1 | EKY29591.1 | HMPREF0216_03269 | HMPREF0216_00174 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate--ammonia ligase, catalytic domain protein; KEGG: cbk:CLL_A0073 8.5e-258 glutamine synthetase; K01915 glutamine synthetase; Psort location: Cytoplasmic, score: 9.67. | 0.477 |
| EKY22381.1 | guaA | HMPREF0216_03269 | HMPREF0216_03257 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.931 |
| EKY22381.1 | murD | HMPREF0216_03269 | HMPREF0216_02734 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.584 |
| EKY22381.1 | murI | HMPREF0216_03269 | HMPREF0216_00033 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.926 |
| EKY26247.1 | EKY22381.1 | HMPREF0216_02029 | HMPREF0216_03269 | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.697 |
| EKY26247.1 | EKY27430.1 | HMPREF0216_02029 | HMPREF0216_01379 | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | Glutamine synthetase, beta-grasp domain protein; KEGG: cth:Cthe_0202 9.2e-158 L-glutamine synthetase K01915; Psort location: Cytoplasmic, score: 9.97. | 0.852 |
| EKY26247.1 | EKY28426.1 | HMPREF0216_02029 | HMPREF0216_00777 | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | Class II glutamine amidotransferase. | 0.908 |
| EKY26247.1 | EKY29456.1 | HMPREF0216_02029 | HMPREF0216_00221 | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | Glu/Leu/Phe/Val dehydrogenase, dimerization domain protein; KEGG: cbk:CLL_A0779 2.7e-190 gluD; glutamate dehydrogenase K00262; Psort location: Cytoplasmic, score: 9.97; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.865 |
| EKY26247.1 | EKY29591.1 | HMPREF0216_02029 | HMPREF0216_00174 | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | Glutamate--ammonia ligase, catalytic domain protein; KEGG: cbk:CLL_A0073 8.5e-258 glutamine synthetase; K01915 glutamine synthetase; Psort location: Cytoplasmic, score: 9.67. | 0.883 |
| EKY26247.1 | glsA | HMPREF0216_02029 | HMPREF0216_02184 | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | Glutaminase A; KEGG: cpr:CPR_1963 6.8e-107 glutaminase K01425; Psort location: Cytoplasmic, score: 7.50; Belongs to the glutaminase family. | 0.567 |
| EKY26247.1 | guaA | HMPREF0216_02029 | HMPREF0216_03257 | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.995 |
| EKY26247.1 | murD | HMPREF0216_02029 | HMPREF0216_02734 | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.801 |
| EKY26247.1 | murI | HMPREF0216_02029 | HMPREF0216_00033 | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.807 |
| EKY27430.1 | EKY22381.1 | HMPREF0216_01379 | HMPREF0216_03269 | Glutamine synthetase, beta-grasp domain protein; KEGG: cth:Cthe_0202 9.2e-158 L-glutamine synthetase K01915; Psort location: Cytoplasmic, score: 9.97. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.477 |
| EKY27430.1 | EKY26247.1 | HMPREF0216_01379 | HMPREF0216_02029 | Glutamine synthetase, beta-grasp domain protein; KEGG: cth:Cthe_0202 9.2e-158 L-glutamine synthetase K01915; Psort location: Cytoplasmic, score: 9.97. | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | 0.852 |
| EKY27430.1 | EKY28426.1 | HMPREF0216_01379 | HMPREF0216_00777 | Glutamine synthetase, beta-grasp domain protein; KEGG: cth:Cthe_0202 9.2e-158 L-glutamine synthetase K01915; Psort location: Cytoplasmic, score: 9.97. | Class II glutamine amidotransferase. | 0.952 |
