| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EKY27781.1 | EKY29623.1 | HMPREF0216_01255 | HMPREF0216_00115 | Methyltransferase small domain protein; KEGG: ctc:CTC00225 1.6e-80 methyltransferase K00599; Psort location: Cytoplasmic, score: 7.50. | DHHA1 domain protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family. | 0.498 |
| EKY27781.1 | tmcAL | HMPREF0216_01255 | HMPREF0216_01801 | Methyltransferase small domain protein; KEGG: ctc:CTC00225 1.6e-80 methyltransferase K00599; Psort location: Cytoplasmic, score: 7.50. | Hypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac- AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. | 0.731 |
| EKY28545.1 | EKY29623.1 | HMPREF0216_00743 | HMPREF0216_00115 | YbbR-like protein. | DHHA1 domain protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family. | 0.649 |
| EKY28545.1 | dacA | HMPREF0216_00743 | HMPREF0216_00744 | YbbR-like protein. | TIGR00159 family protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. | 0.946 |
| EKY29620.1 | EKY29621.1 | HMPREF0216_00112 | HMPREF0216_00113 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | ATP-dependent protease, Lon family; KEGG: cpr:CPR_2649 1.4e-250 ATP-dependent protease; K01338 ATP-dependent Lon protease; Psort location: Cytoplasmic, score: 9.97. | 0.508 |
| EKY29620.1 | EKY29623.1 | HMPREF0216_00112 | HMPREF0216_00115 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | DHHA1 domain protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family. | 0.588 |
| EKY29620.1 | EKY29624.1 | HMPREF0216_00112 | HMPREF0216_00116 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | Hypothetical protein; Psort location: Cytoplasmic, score: 7.50. | 0.476 |
| EKY29620.1 | rplI | HMPREF0216_00112 | HMPREF0216_00114 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | Ribosomal protein L9; Binds to the 23S rRNA. | 0.735 |
| EKY29620.1 | rpsR | HMPREF0216_00112 | HMPREF0216_00117 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | Ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. | 0.495 |
| EKY29621.1 | EKY29620.1 | HMPREF0216_00113 | HMPREF0216_00112 | ATP-dependent protease, Lon family; KEGG: cpr:CPR_2649 1.4e-250 ATP-dependent protease; K01338 ATP-dependent Lon protease; Psort location: Cytoplasmic, score: 9.97. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | 0.508 |
| EKY29621.1 | EKY29623.1 | HMPREF0216_00113 | HMPREF0216_00115 | ATP-dependent protease, Lon family; KEGG: cpr:CPR_2649 1.4e-250 ATP-dependent protease; K01338 ATP-dependent Lon protease; Psort location: Cytoplasmic, score: 9.97. | DHHA1 domain protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family. | 0.704 |
| EKY29621.1 | EKY29624.1 | HMPREF0216_00113 | HMPREF0216_00116 | ATP-dependent protease, Lon family; KEGG: cpr:CPR_2649 1.4e-250 ATP-dependent protease; K01338 ATP-dependent Lon protease; Psort location: Cytoplasmic, score: 9.97. | Hypothetical protein; Psort location: Cytoplasmic, score: 7.50. | 0.500 |
| EKY29621.1 | rplI | HMPREF0216_00113 | HMPREF0216_00114 | ATP-dependent protease, Lon family; KEGG: cpr:CPR_2649 1.4e-250 ATP-dependent protease; K01338 ATP-dependent Lon protease; Psort location: Cytoplasmic, score: 9.97. | Ribosomal protein L9; Binds to the 23S rRNA. | 0.773 |
| EKY29623.1 | EKY27781.1 | HMPREF0216_00115 | HMPREF0216_01255 | DHHA1 domain protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family. | Methyltransferase small domain protein; KEGG: ctc:CTC00225 1.6e-80 methyltransferase K00599; Psort location: Cytoplasmic, score: 7.50. | 0.498 |
| EKY29623.1 | EKY28545.1 | HMPREF0216_00115 | HMPREF0216_00743 | DHHA1 domain protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family. | YbbR-like protein. | 0.649 |
| EKY29623.1 | EKY29620.1 | HMPREF0216_00115 | HMPREF0216_00112 | DHHA1 domain protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | 0.588 |
| EKY29623.1 | EKY29621.1 | HMPREF0216_00115 | HMPREF0216_00113 | DHHA1 domain protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family. | ATP-dependent protease, Lon family; KEGG: cpr:CPR_2649 1.4e-250 ATP-dependent protease; K01338 ATP-dependent Lon protease; Psort location: Cytoplasmic, score: 9.97. | 0.704 |
| EKY29623.1 | EKY29624.1 | HMPREF0216_00115 | HMPREF0216_00116 | DHHA1 domain protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family. | Hypothetical protein; Psort location: Cytoplasmic, score: 7.50. | 0.631 |
| EKY29623.1 | EKY29628.1 | HMPREF0216_00115 | HMPREF0216_00120 | DHHA1 domain protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family. | Hypothetical protein; Psort location: Cytoplasmic, score: 7.50. | 0.599 |
| EKY29623.1 | dacA | HMPREF0216_00115 | HMPREF0216_00744 | DHHA1 domain protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family. | TIGR00159 family protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. | 0.518 |