STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nfoApurinic endonuclease; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (278 aa)    
Predicted Functional Partners:
EKY26229.1
Exodeoxyribonuclease III.
    
 0.904
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 
 0.780
ung
uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
   
 
 0.601
EKY28580.1
KEGG: cbt:CLH_0367 2.4e-111 8-oxoguanine DNA glycosylase; K03660 N-glycosylase/DNA lyase; Psort location: Cytoplasmic, score: 7.50.
    
 
 0.561
EKY28806.1
ErfK/YbiS/YcfS/YnhG; KEGG: pfa:PF10_0191 0.00014 tRNA methyltransferase, putative.
       0.529
EKY26309.1
Dinuclear metal center protein, YbgI family; KEGG: hip:CGSHiEE_02770 3.4e-18 seryl-tRNA synthetase; Psort location: Cytoplasmic, score: 7.50.
     
 0.529
polA
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
   
 
 0.510
EKY26451.1
AP endonuclease, family 2; KEGG: sat:SYN_01340 3.4e-18 endonuclease IV K01151; Psort location: Cytoplasmic, score: 7.50.
     
 0.491
EKY28808.1
Hypothetical protein; KEGG: slg:SLGD_01278 0.0050 ACT domain-containing protein; K06209 chorismate mutase.
       0.490
EKY24034.1
S1 RNA binding domain protein.
  
    0.448
Your Current Organism:
Clostridium celatum
NCBI taxonomy Id: 545697
Other names: C. celatum DSM 1785, Clostridium celatum DSM 1785
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