| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EKY24632.1 | EKY26137.1 | HMPREF0216_02662 | HMPREF0216_02176 | Protein FolC; KEGG: cbk:CLL_A2503 7.7e-138 folylpolyglutamate synthase K11754; Psort location: Cytoplasmic, score: 7.50. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.991 |
| EKY24632.1 | EKY28585.1 | HMPREF0216_02662 | HMPREF0216_00638 | Protein FolC; KEGG: cbk:CLL_A2503 7.7e-138 folylpolyglutamate synthase K11754; Psort location: Cytoplasmic, score: 7.50. | Oxidoreductase. | 0.544 |
| EKY24632.1 | fhs | HMPREF0216_02662 | HMPREF0216_02543 | Protein FolC; KEGG: cbk:CLL_A2503 7.7e-138 folylpolyglutamate synthase K11754; Psort location: Cytoplasmic, score: 7.50. | KEGG: cbe:Cbei_0101 2.5e-251 formate--tetrahydrofolate ligase K01938; Psort location: Cytoplasmic, score: 7.50. | 0.688 |
| EKY24632.1 | glyA | HMPREF0216_02662 | HMPREF0216_02267 | Protein FolC; KEGG: cbk:CLL_A2503 7.7e-138 folylpolyglutamate synthase K11754; Psort location: Cytoplasmic, score: 7.50. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.681 |
| EKY24632.1 | thyA | HMPREF0216_02662 | HMPREF0216_00285 | Protein FolC; KEGG: cbk:CLL_A2503 7.7e-138 folylpolyglutamate synthase K11754; Psort location: Cytoplasmic, score: 7.50. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.842 |
| EKY26110.1 | EKY28585.1 | HMPREF0216_02149 | HMPREF0216_00638 | KEGG: cbk:CLL_A2853 3.0e-271 5-methyltetrahydrofolate--homocysteine methyltransferase; K00548 5-methyltetrahydrofolate--homocysteine methyltransferase; Psort location: Cytoplasmic, score: 7.50. | Oxidoreductase. | 0.829 |
| EKY26110.1 | fhs | HMPREF0216_02149 | HMPREF0216_02543 | KEGG: cbk:CLL_A2853 3.0e-271 5-methyltetrahydrofolate--homocysteine methyltransferase; K00548 5-methyltetrahydrofolate--homocysteine methyltransferase; Psort location: Cytoplasmic, score: 7.50. | KEGG: cbe:Cbei_0101 2.5e-251 formate--tetrahydrofolate ligase K01938; Psort location: Cytoplasmic, score: 7.50. | 0.953 |
| EKY26110.1 | fmt | HMPREF0216_02149 | HMPREF0216_01819 | KEGG: cbk:CLL_A2853 3.0e-271 5-methyltetrahydrofolate--homocysteine methyltransferase; K00548 5-methyltetrahydrofolate--homocysteine methyltransferase; Psort location: Cytoplasmic, score: 7.50. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.819 |
| EKY26110.1 | glyA | HMPREF0216_02149 | HMPREF0216_02267 | KEGG: cbk:CLL_A2853 3.0e-271 5-methyltetrahydrofolate--homocysteine methyltransferase; K00548 5-methyltetrahydrofolate--homocysteine methyltransferase; Psort location: Cytoplasmic, score: 7.50. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.878 |
| EKY26110.1 | msrA | HMPREF0216_02149 | HMPREF0216_00863 | KEGG: cbk:CLL_A2853 3.0e-271 5-methyltetrahydrofolate--homocysteine methyltransferase; K00548 5-methyltetrahydrofolate--homocysteine methyltransferase; Psort location: Cytoplasmic, score: 7.50. | methionine-R-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.689 |
| EKY26110.1 | thyA | HMPREF0216_02149 | HMPREF0216_00285 | KEGG: cbk:CLL_A2853 3.0e-271 5-methyltetrahydrofolate--homocysteine methyltransferase; K00548 5-methyltetrahydrofolate--homocysteine methyltransferase; Psort location: Cytoplasmic, score: 7.50. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.828 |
| EKY26137.1 | EKY24632.1 | HMPREF0216_02176 | HMPREF0216_02662 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Protein FolC; KEGG: cbk:CLL_A2503 7.7e-138 folylpolyglutamate synthase K11754; Psort location: Cytoplasmic, score: 7.50. | 0.991 |
| EKY26137.1 | EKY28585.1 | HMPREF0216_02176 | HMPREF0216_00638 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Oxidoreductase. | 0.555 |
| EKY26137.1 | fhs | HMPREF0216_02176 | HMPREF0216_02543 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | KEGG: cbe:Cbei_0101 2.5e-251 formate--tetrahydrofolate ligase K01938; Psort location: Cytoplasmic, score: 7.50. | 0.560 |
| EKY26137.1 | fmt | HMPREF0216_02176 | HMPREF0216_01819 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.563 |
| EKY26137.1 | glyA | HMPREF0216_02176 | HMPREF0216_02267 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.486 |
| EKY26137.1 | msrA | HMPREF0216_02176 | HMPREF0216_00863 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | methionine-R-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.499 |
| EKY28585.1 | EKY24632.1 | HMPREF0216_00638 | HMPREF0216_02662 | Oxidoreductase. | Protein FolC; KEGG: cbk:CLL_A2503 7.7e-138 folylpolyglutamate synthase K11754; Psort location: Cytoplasmic, score: 7.50. | 0.544 |
| EKY28585.1 | EKY26110.1 | HMPREF0216_00638 | HMPREF0216_02149 | Oxidoreductase. | KEGG: cbk:CLL_A2853 3.0e-271 5-methyltetrahydrofolate--homocysteine methyltransferase; K00548 5-methyltetrahydrofolate--homocysteine methyltransferase; Psort location: Cytoplasmic, score: 7.50. | 0.829 |
| EKY28585.1 | EKY26137.1 | HMPREF0216_00638 | HMPREF0216_02176 | Oxidoreductase. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.555 |