| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EKY21954.1 | EKY25255.1 | HMPREF0216_03478 | HMPREF0216_02545 | Hypothetical protein; KEGG: cpy:Cphy_3915 6.2e-49 guanylate kinase/L-type calcium channel region; K00942 guanylate kinase; Psort location: Cytoplasmic, score: 7.50. | KEGG: cbe:Cbei_0099 2.3e-67 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.639 |
| EKY21954.1 | EKY26178.1 | HMPREF0216_03478 | HMPREF0216_02217 | Hypothetical protein; KEGG: cpy:Cphy_3915 6.2e-49 guanylate kinase/L-type calcium channel region; K00942 guanylate kinase; Psort location: Cytoplasmic, score: 7.50. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.639 |
| EKY21954.1 | EKY27162.1 | HMPREF0216_03478 | HMPREF0216_01527 | Hypothetical protein; KEGG: cpy:Cphy_3915 6.2e-49 guanylate kinase/L-type calcium channel region; K00942 guanylate kinase; Psort location: Cytoplasmic, score: 7.50. | Adenylosuccinate lyase; KEGG: cpr:CPR_1640 1.9e-205 purB; adenylosuccinate lyase K01756; Psort location: Cytoplasmic, score: 7.50. | 0.816 |
| EKY21954.1 | gmk | HMPREF0216_03478 | HMPREF0216_01824 | Hypothetical protein; KEGG: cpy:Cphy_3915 6.2e-49 guanylate kinase/L-type calcium channel region; K00942 guanylate kinase; Psort location: Cytoplasmic, score: 7.50. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.612 |
| EKY21954.1 | guaA | HMPREF0216_03478 | HMPREF0216_03257 | Hypothetical protein; KEGG: cpy:Cphy_3915 6.2e-49 guanylate kinase/L-type calcium channel region; K00942 guanylate kinase; Psort location: Cytoplasmic, score: 7.50. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.946 |
| EKY21954.1 | guaB | HMPREF0216_03478 | HMPREF0216_03256 | Hypothetical protein; KEGG: cpy:Cphy_3915 6.2e-49 guanylate kinase/L-type calcium channel region; K00942 guanylate kinase; Psort location: Cytoplasmic, score: 7.50. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.477 |
| EKY21954.1 | xpt | HMPREF0216_03478 | HMPREF0216_00659 | Hypothetical protein; KEGG: cpy:Cphy_3915 6.2e-49 guanylate kinase/L-type calcium channel region; K00942 guanylate kinase; Psort location: Cytoplasmic, score: 7.50. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.837 |
| EKY22381.1 | EKY25255.1 | HMPREF0216_03269 | HMPREF0216_02545 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | KEGG: cbe:Cbei_0099 2.3e-67 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.798 |
| EKY22381.1 | EKY26178.1 | HMPREF0216_03269 | HMPREF0216_02217 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.798 |
| EKY22381.1 | guaA | HMPREF0216_03269 | HMPREF0216_03257 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.931 |
| EKY22381.1 | guaB | HMPREF0216_03269 | HMPREF0216_03256 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.843 |
| EKY22381.1 | xpt | HMPREF0216_03269 | HMPREF0216_00659 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.834 |
| EKY25255.1 | EKY21954.1 | HMPREF0216_02545 | HMPREF0216_03478 | KEGG: cbe:Cbei_0099 2.3e-67 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Hypothetical protein; KEGG: cpy:Cphy_3915 6.2e-49 guanylate kinase/L-type calcium channel region; K00942 guanylate kinase; Psort location: Cytoplasmic, score: 7.50. | 0.639 |
| EKY25255.1 | EKY22381.1 | HMPREF0216_02545 | HMPREF0216_03269 | KEGG: cbe:Cbei_0099 2.3e-67 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.798 |
| EKY25255.1 | EKY26178.1 | HMPREF0216_02545 | HMPREF0216_02217 | KEGG: cbe:Cbei_0099 2.3e-67 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.793 |
| EKY25255.1 | EKY27162.1 | HMPREF0216_02545 | HMPREF0216_01527 | KEGG: cbe:Cbei_0099 2.3e-67 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenylosuccinate lyase; KEGG: cpr:CPR_1640 1.9e-205 purB; adenylosuccinate lyase K01756; Psort location: Cytoplasmic, score: 7.50. | 0.572 |
| EKY25255.1 | EKY27256.1 | HMPREF0216_02545 | HMPREF0216_01508 | KEGG: cbe:Cbei_0099 2.3e-67 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.928 |
| EKY25255.1 | deoD | HMPREF0216_02545 | HMPREF0216_02663 | KEGG: cbe:Cbei_0099 2.3e-67 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | KEGG: cno:NT01CX_2329 4.4e-80 deoD; purine nucleoside phosphorylase K03784; Psort location: Cytoplasmic, score: 9.67. | 0.900 |
| EKY25255.1 | gmk | HMPREF0216_02545 | HMPREF0216_01824 | KEGG: cbe:Cbei_0099 2.3e-67 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.837 |
| EKY25255.1 | guaA | HMPREF0216_02545 | HMPREF0216_03257 | KEGG: cbe:Cbei_0099 2.3e-67 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.909 |
