STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (356 aa)    
Predicted Functional Partners:
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
 
 0.999
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 0.999
EKY28538.1
KEGG: cbe:Cbei_0212 6.6e-61 acetolactate synthase, small subunit; K01653 acetolactate synthase I/III small subunit; Psort location: Cytoplasmic, score: 7.50.
 
 0.993
ilvD
KEGG: ccb:Clocel_1323 4.9e-223 dihydroxy-acid dehydratase K01687; Psort location: Cytoplasmic, score: 7.50; Belongs to the IlvD/Edd family.
 
  
 0.991
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.990
EKY28532.1
KEGG: cbk:CLL_A0326 5.0e-214 ilvB; acetolactate synthase, large subunit, biosynthetic type K01652; Psort location: Cytoplasmic, score: 9.95.
 
 0.987
EKY28537.1
2-isopropylmalate synthase/homocitrate synthase family protein; KEGG: cbe:Cbei_0213 1.1e-211 putative alpha-isopropylmalate/homocitrate synthase family transferase K01649; Psort location: Cytoplasmic, score: 9.97; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 0.963
EKY27924.1
KEGG: cbe:Cbei_0070 3.6e-282 aconitate hydratase K01681; Psort location: Cytoplasmic, score: 9.97.
 0.955
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 0.950
EKY28426.1
Class II glutamine amidotransferase.
  
 
 0.942
Your Current Organism:
Clostridium celatum
NCBI taxonomy Id: 545697
Other names: C. celatum DSM 1785, Clostridium celatum DSM 1785
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