| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EKY22505.1 | EKY28433.1 | HMPREF0216_03228 | HMPREF0216_00784 | HAD hydrolase, family IIB; KEGG: bmq:BMQ_2844 9.9e-19 haloacid dehalogenase-like hydrolase K07024; Psort location: Cytoplasmic, score: 7.50. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.816 |
| EKY22505.1 | EKY28434.1 | HMPREF0216_03228 | HMPREF0216_00785 | HAD hydrolase, family IIB; KEGG: bmq:BMQ_2844 9.9e-19 haloacid dehalogenase-like hydrolase K07024; Psort location: Cytoplasmic, score: 7.50. | Riboflavin synthase, alpha subunit. | 0.793 |
| EKY22505.1 | ribBA | HMPREF0216_03228 | HMPREF0216_00786 | HAD hydrolase, family IIB; KEGG: bmq:BMQ_2844 9.9e-19 haloacid dehalogenase-like hydrolase K07024; Psort location: Cytoplasmic, score: 7.50. | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.514 |
| EKY22505.1 | ribH | HMPREF0216_03228 | HMPREF0216_00787 | HAD hydrolase, family IIB; KEGG: bmq:BMQ_2844 9.9e-19 haloacid dehalogenase-like hydrolase K07024; Psort location: Cytoplasmic, score: 7.50. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.796 |
| EKY26632.1 | EKY28433.1 | HMPREF0216_01817 | HMPREF0216_00784 | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.815 |
| EKY26632.1 | EKY28434.1 | HMPREF0216_01817 | HMPREF0216_00785 | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Riboflavin synthase, alpha subunit. | 0.406 |
| EKY26632.1 | metK | HMPREF0216_01817 | HMPREF0216_03355 | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.618 |
| EKY26632.1 | pyrB | HMPREF0216_01817 | HMPREF0216_02205 | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.406 |
| EKY26632.1 | ribBA | HMPREF0216_01817 | HMPREF0216_00786 | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.818 |
| EKY26632.1 | ribH | HMPREF0216_01817 | HMPREF0216_00787 | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.799 |
| EKY26632.1 | rplU | HMPREF0216_01817 | HMPREF0216_03306 | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. | 0.733 |
| EKY28433.1 | EKY22505.1 | HMPREF0216_00784 | HMPREF0216_03228 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | HAD hydrolase, family IIB; KEGG: bmq:BMQ_2844 9.9e-19 haloacid dehalogenase-like hydrolase K07024; Psort location: Cytoplasmic, score: 7.50. | 0.816 |
| EKY28433.1 | EKY26632.1 | HMPREF0216_00784 | HMPREF0216_01817 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.815 |
| EKY28433.1 | EKY28434.1 | HMPREF0216_00784 | HMPREF0216_00785 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Riboflavin synthase, alpha subunit. | 0.999 |
| EKY28433.1 | EKY28437.1 | HMPREF0216_00784 | HMPREF0216_00788 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Haloacid dehalogenase-like hydrolase. | 0.772 |
| EKY28433.1 | metK | HMPREF0216_00784 | HMPREF0216_03355 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.713 |
| EKY28433.1 | nusB | HMPREF0216_00784 | HMPREF0216_01601 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Transcription antitermination factor NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.661 |
| EKY28433.1 | ribBA | HMPREF0216_00784 | HMPREF0216_00786 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.999 |
| EKY28433.1 | ribH | HMPREF0216_00784 | HMPREF0216_00787 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.996 |
| EKY28434.1 | EKY22505.1 | HMPREF0216_00785 | HMPREF0216_03228 | Riboflavin synthase, alpha subunit. | HAD hydrolase, family IIB; KEGG: bmq:BMQ_2844 9.9e-19 haloacid dehalogenase-like hydrolase K07024; Psort location: Cytoplasmic, score: 7.50. | 0.793 |