Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mnmAtRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (361 aa)    
Predicted Functional Partners:
iscS
Cysteine desulfurase NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
 
  
 0.920
EKY27855.1
Fe-S iron-sulfur cluster assembly protein, NifU family; KEGG: rxy:Rxyl_1354 5.7e-21 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase K00566; Psort location: Cytoplasmic, score: 7.50.
  
  
 0.821
EKY27857.1
Putative HTH-type transcriptional regulator IscR; KEGG: hdn:Hden_2359 1.1e-18 transcriptional regulator, Rrf2 family; Psort location: Cytoplasmic, score: 7.50.
  
  
 0.790
EKY27643.1
Hypothetical protein; KEGG: sat:SYN_01419 4.0e-70 putative tRNA (5-methylaminomethyl-2-thiouridylate) -methyltransferase / fibronectin/fibrinogen-binding protein K00566; Psort location: Cytoplasmic, score: 7.50.
     
  0.776
mnmE
tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
 
 
 0.618
thiI
Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
 
 0.607
EKY23482.1
Tetratricopeptide repeat protein; KEGG: ava:Ava_1552 5.1e-10 TPR repeat-containing serine/threonin protein kinase K00908; Psort location: Cytoplasmic, score: 7.50.
  
 
  0.600
EKY27858.1
ATPase, AAA family; KEGG: ava:Ava_B0112 3.3e-82 recombination factor protein RarA/unknown domain fusion protein K07478; Psort location: Cytoplasmic, score: 7.50.
     
 0.583
tilS
tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family.
 
 
 
 0.557
EKY29385.1
Putative cysteine desulfurase; KEGG: cbe:Cbei_1312 1.2e-125 aminotransferase, class V; K04487 cysteine desulfurase; Psort location: Cytoplasmic, score: 9.97.
 
  
 0.547
Your Current Organism:
Clostridium celatum
NCBI taxonomy Id: 545697
Other names: C. celatum DSM 1785, Clostridium celatum DSM 1785
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