| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EKY22374.1 | EKY27784.1 | HMPREF0216_03262 | HMPREF0216_01259 | Pseudouridylate synthase; KEGG: cbe:Cbei_0345 9.1e-96 pseudouridine synthase; K06183 ribosomal small subunit pseudouridine synthase A; Psort location: Cytoplasmic, score: 9.97; Belongs to the pseudouridine synthase RsuA family. | HAD hydrolase, family IA, variant 3; KEGG: bde:BDP_1275 1.1e-37 haloacid dehalogenase-like hydrolase (HAD superfamily); Psort location: Cytoplasmic, score: 7.50. | 0.511 |
| EKY22381.1 | EKY27784.1 | HMPREF0216_03269 | HMPREF0216_01259 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | HAD hydrolase, family IA, variant 3; KEGG: bde:BDP_1275 1.1e-37 haloacid dehalogenase-like hydrolase (HAD superfamily); Psort location: Cytoplasmic, score: 7.50. | 0.502 |
| EKY22381.1 | guaA | HMPREF0216_03269 | HMPREF0216_03257 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.931 |
| EKY22381.1 | purH | HMPREF0216_03269 | HMPREF0216_02023 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | KEGG: cpe:CPE0686 5.5e-215 purH; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase K00602; Psort location: Cytoplasmic, score: 7.50. | 0.831 |
| EKY24021.1 | EKY27784.1 | HMPREF0216_02780 | HMPREF0216_01259 | Pullulanase, type I; Belongs to the glycosyl hydrolase 13 family. | HAD hydrolase, family IA, variant 3; KEGG: bde:BDP_1275 1.1e-37 haloacid dehalogenase-like hydrolase (HAD superfamily); Psort location: Cytoplasmic, score: 7.50. | 0.674 |
| EKY24021.1 | guaA | HMPREF0216_02780 | HMPREF0216_03257 | Pullulanase, type I; Belongs to the glycosyl hydrolase 13 family. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.432 |
| EKY25815.1 | EKY26446.1 | HMPREF0216_02397 | HMPREF0216_01942 | Phosphomethylpyrimidine kinase. | FAD dependent oxidoreductase; KEGG: ctc:CTC00417 9.5e-101 oxidoreductase K00100; Psort location: Cytoplasmic, score: 7.50. | 0.432 |
| EKY25815.1 | EKY27784.1 | HMPREF0216_02397 | HMPREF0216_01259 | Phosphomethylpyrimidine kinase. | HAD hydrolase, family IA, variant 3; KEGG: bde:BDP_1275 1.1e-37 haloacid dehalogenase-like hydrolase (HAD superfamily); Psort location: Cytoplasmic, score: 7.50. | 0.681 |
| EKY25815.1 | guaA | HMPREF0216_02397 | HMPREF0216_03257 | Phosphomethylpyrimidine kinase. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.453 |
| EKY25815.1 | thiE | HMPREF0216_02397 | HMPREF0216_02393 | Phosphomethylpyrimidine kinase. | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.999 |
| EKY26446.1 | EKY25815.1 | HMPREF0216_01942 | HMPREF0216_02397 | FAD dependent oxidoreductase; KEGG: ctc:CTC00417 9.5e-101 oxidoreductase K00100; Psort location: Cytoplasmic, score: 7.50. | Phosphomethylpyrimidine kinase. | 0.432 |
| EKY26446.1 | EKY27784.1 | HMPREF0216_01942 | HMPREF0216_01259 | FAD dependent oxidoreductase; KEGG: ctc:CTC00417 9.5e-101 oxidoreductase K00100; Psort location: Cytoplasmic, score: 7.50. | HAD hydrolase, family IA, variant 3; KEGG: bde:BDP_1275 1.1e-37 haloacid dehalogenase-like hydrolase (HAD superfamily); Psort location: Cytoplasmic, score: 7.50. | 0.499 |
| EKY26446.1 | EKY29328.1 | HMPREF0216_01942 | HMPREF0216_00296 | FAD dependent oxidoreductase; KEGG: ctc:CTC00417 9.5e-101 oxidoreductase K00100; Psort location: Cytoplasmic, score: 7.50. | Aminotransferase, class V; KEGG: cpr:CPR_0063 6.6e-148 aminotransferase, class V; K00839 aminotransferase; Psort location: Cytoplasmic, score: 9.97. | 0.852 |
| EKY26446.1 | guaA | HMPREF0216_01942 | HMPREF0216_03257 | FAD dependent oxidoreductase; KEGG: ctc:CTC00417 9.5e-101 oxidoreductase K00100; Psort location: Cytoplasmic, score: 7.50. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.438 |
| EKY26446.1 | purH | HMPREF0216_01942 | HMPREF0216_02023 | FAD dependent oxidoreductase; KEGG: ctc:CTC00417 9.5e-101 oxidoreductase K00100; Psort location: Cytoplasmic, score: 7.50. | KEGG: cpe:CPE0686 5.5e-215 purH; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase K00602; Psort location: Cytoplasmic, score: 7.50. | 0.609 |
| EKY26446.1 | thiE | HMPREF0216_01942 | HMPREF0216_02393 | FAD dependent oxidoreductase; KEGG: ctc:CTC00417 9.5e-101 oxidoreductase K00100; Psort location: Cytoplasmic, score: 7.50. | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.611 |
| EKY27784.1 | EKY22374.1 | HMPREF0216_01259 | HMPREF0216_03262 | HAD hydrolase, family IA, variant 3; KEGG: bde:BDP_1275 1.1e-37 haloacid dehalogenase-like hydrolase (HAD superfamily); Psort location: Cytoplasmic, score: 7.50. | Pseudouridylate synthase; KEGG: cbe:Cbei_0345 9.1e-96 pseudouridine synthase; K06183 ribosomal small subunit pseudouridine synthase A; Psort location: Cytoplasmic, score: 9.97; Belongs to the pseudouridine synthase RsuA family. | 0.511 |
| EKY27784.1 | EKY22381.1 | HMPREF0216_01259 | HMPREF0216_03269 | HAD hydrolase, family IA, variant 3; KEGG: bde:BDP_1275 1.1e-37 haloacid dehalogenase-like hydrolase (HAD superfamily); Psort location: Cytoplasmic, score: 7.50. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.502 |
| EKY27784.1 | EKY24021.1 | HMPREF0216_01259 | HMPREF0216_02780 | HAD hydrolase, family IA, variant 3; KEGG: bde:BDP_1275 1.1e-37 haloacid dehalogenase-like hydrolase (HAD superfamily); Psort location: Cytoplasmic, score: 7.50. | Pullulanase, type I; Belongs to the glycosyl hydrolase 13 family. | 0.674 |
| EKY27784.1 | EKY25815.1 | HMPREF0216_01259 | HMPREF0216_02397 | HAD hydrolase, family IA, variant 3; KEGG: bde:BDP_1275 1.1e-37 haloacid dehalogenase-like hydrolase (HAD superfamily); Psort location: Cytoplasmic, score: 7.50. | Phosphomethylpyrimidine kinase. | 0.681 |