| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EKY23243.1 | EKY27840.1 | HMPREF0216_03028 | HMPREF0216_01197 | Hypothetical protein; KEGG: cpy:Cphy_3050 1.4e-27 anaerobic ribonucleoside triphosphate reductase K00527; Psort location: Cytoplasmic, score: 7.50. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.412 |
| EKY23243.1 | EKY27926.1 | HMPREF0216_03028 | HMPREF0216_01091 | Hypothetical protein; KEGG: cpy:Cphy_3050 1.4e-27 anaerobic ribonucleoside triphosphate reductase K00527; Psort location: Cytoplasmic, score: 7.50. | Hypothetical protein; KEGG: cbe:Cbei_0068 1.3e-78 anaerobic ribonucleoside triphosphate reductase K00527; Psort location: Cytoplasmic, score: 7.50. | 0.621 |
| EKY23243.1 | EKY27927.1 | HMPREF0216_03028 | HMPREF0216_01092 | Hypothetical protein; KEGG: cpy:Cphy_3050 1.4e-27 anaerobic ribonucleoside triphosphate reductase K00527; Psort location: Cytoplasmic, score: 7.50. | KEGG: cpf:CPF_2830 7.7e-225 nrdD; anaerobic ribonucleoside triphosphate reductase K00527; Psort location: Cytoplasmic, score: 7.50. | 0.814 |
| EKY23243.1 | dut | HMPREF0216_03028 | HMPREF0216_01409 | Hypothetical protein; KEGG: cpy:Cphy_3050 1.4e-27 anaerobic ribonucleoside triphosphate reductase K00527; Psort location: Cytoplasmic, score: 7.50. | Putative dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.786 |
| EKY23243.1 | ndk | HMPREF0216_03028 | HMPREF0216_02073 | Hypothetical protein; KEGG: cpy:Cphy_3050 1.4e-27 anaerobic ribonucleoside triphosphate reductase K00527; Psort location: Cytoplasmic, score: 7.50. | Putative nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.763 |
| EKY26637.1 | dut | HMPREF0216_01822 | HMPREF0216_01409 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Putative dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.930 |
| EKY26637.1 | thyA | HMPREF0216_01822 | HMPREF0216_00285 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.576 |
| EKY27305.1 | EKY27840.1 | HMPREF0216_01469 | HMPREF0216_01197 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.859 |
| EKY27305.1 | dut | HMPREF0216_01469 | HMPREF0216_01409 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Putative dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.887 |
| EKY27305.1 | thyA | HMPREF0216_01469 | HMPREF0216_00285 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.775 |
| EKY27656.1 | dut | HMPREF0216_01299 | HMPREF0216_01409 | KEGG: cpr:CPR_1134 1.4e-58 cytidine/deoxycytidylate deaminase family protein; K01493 dCMP deaminase; Psort location: Cytoplasmic, score: 7.50. | Putative dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.885 |
| EKY27656.1 | tdk | HMPREF0216_01299 | HMPREF0216_01292 | KEGG: cpr:CPR_1134 1.4e-58 cytidine/deoxycytidylate deaminase family protein; K01493 dCMP deaminase; Psort location: Cytoplasmic, score: 7.50. | Thymidine kinase; KEGG: cbt:CLH_0472 8.2e-79 tdk; thymidine kinase K00857; Psort location: Cytoplasmic, score: 7.50. | 0.887 |
| EKY27656.1 | thyA | HMPREF0216_01299 | HMPREF0216_00285 | KEGG: cpr:CPR_1134 1.4e-58 cytidine/deoxycytidylate deaminase family protein; K01493 dCMP deaminase; Psort location: Cytoplasmic, score: 7.50. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.933 |
| EKY27840.1 | EKY23243.1 | HMPREF0216_01197 | HMPREF0216_03028 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Hypothetical protein; KEGG: cpy:Cphy_3050 1.4e-27 anaerobic ribonucleoside triphosphate reductase K00527; Psort location: Cytoplasmic, score: 7.50. | 0.412 |
| EKY27840.1 | EKY27305.1 | HMPREF0216_01197 | HMPREF0216_01469 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.859 |
| EKY27840.1 | EKY27926.1 | HMPREF0216_01197 | HMPREF0216_01091 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Hypothetical protein; KEGG: cbe:Cbei_0068 1.3e-78 anaerobic ribonucleoside triphosphate reductase K00527; Psort location: Cytoplasmic, score: 7.50. | 0.412 |
| EKY27840.1 | EKY27927.1 | HMPREF0216_01197 | HMPREF0216_01092 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | KEGG: cpf:CPF_2830 7.7e-225 nrdD; anaerobic ribonucleoside triphosphate reductase K00527; Psort location: Cytoplasmic, score: 7.50. | 0.412 |
| EKY27840.1 | dut | HMPREF0216_01197 | HMPREF0216_01409 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Putative dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.962 |
| EKY27840.1 | ndk | HMPREF0216_01197 | HMPREF0216_02073 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Putative nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.934 |
| EKY27840.1 | tdk | HMPREF0216_01197 | HMPREF0216_01292 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Thymidine kinase; KEGG: cbt:CLH_0472 8.2e-79 tdk; thymidine kinase K00857; Psort location: Cytoplasmic, score: 7.50. | 0.529 |
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