| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EKY26152.1 | murE | HMPREF0216_02191 | HMPREF0216_01561 | CobB/CobQ-like protein; KEGG: lsl:LSL_0587 3.4e-64 cobyric acid synthase K07009; Psort location: Cytoplasmic, score: 7.50. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.896 |
| EKY26152.1 | murG | HMPREF0216_02191 | HMPREF0216_00228 | CobB/CobQ-like protein; KEGG: lsl:LSL_0587 3.4e-64 cobyric acid synthase K07009; Psort location: Cytoplasmic, score: 7.50. | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.802 |
| EKY26957.1 | EKY26961.1 | HMPREF0216_01560 | HMPREF0216_01564 | KEGG: cbe:Cbei_1578 2.3e-239 stage V sporulation protein D K08384; Psort location: CytoplasmicMembrane, score: 9.51. | Stage V sporulation protein E; KEGG: hiq:CGSHiGG_09345 5.9e-53 murD; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase K03588; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the SEDS family. | 0.933 |
| EKY26957.1 | glmU | HMPREF0216_01560 | HMPREF0216_00021 | KEGG: cbe:Cbei_1578 2.3e-239 stage V sporulation protein D K08384; Psort location: CytoplasmicMembrane, score: 9.51. | UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | 0.405 |
| EKY26957.1 | mraY | HMPREF0216_01560 | HMPREF0216_01563 | KEGG: cbe:Cbei_1578 2.3e-239 stage V sporulation protein D K08384; Psort location: CytoplasmicMembrane, score: 9.51. | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | 0.867 |
| EKY26957.1 | murC | HMPREF0216_01560 | HMPREF0216_01507 | KEGG: cbe:Cbei_1578 2.3e-239 stage V sporulation protein D K08384; Psort location: CytoplasmicMembrane, score: 9.51. | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.780 |
| EKY26957.1 | murD | HMPREF0216_01560 | HMPREF0216_02734 | KEGG: cbe:Cbei_1578 2.3e-239 stage V sporulation protein D K08384; Psort location: CytoplasmicMembrane, score: 9.51. | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.793 |
| EKY26957.1 | murE | HMPREF0216_01560 | HMPREF0216_01561 | KEGG: cbe:Cbei_1578 2.3e-239 stage V sporulation protein D K08384; Psort location: CytoplasmicMembrane, score: 9.51. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.854 |
| EKY26957.1 | murF | HMPREF0216_01560 | HMPREF0216_01562 | KEGG: cbe:Cbei_1578 2.3e-239 stage V sporulation protein D K08384; Psort location: CytoplasmicMembrane, score: 9.51. | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.918 |
| EKY26957.1 | murG | HMPREF0216_01560 | HMPREF0216_00228 | KEGG: cbe:Cbei_1578 2.3e-239 stage V sporulation protein D K08384; Psort location: CytoplasmicMembrane, score: 9.51. | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.489 |
| EKY26961.1 | EKY26957.1 | HMPREF0216_01564 | HMPREF0216_01560 | Stage V sporulation protein E; KEGG: hiq:CGSHiGG_09345 5.9e-53 murD; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase K03588; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the SEDS family. | KEGG: cbe:Cbei_1578 2.3e-239 stage V sporulation protein D K08384; Psort location: CytoplasmicMembrane, score: 9.51. | 0.933 |
| EKY26961.1 | mraY | HMPREF0216_01564 | HMPREF0216_01563 | Stage V sporulation protein E; KEGG: hiq:CGSHiGG_09345 5.9e-53 murD; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase K03588; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the SEDS family. | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | 0.929 |
| EKY26961.1 | murC | HMPREF0216_01564 | HMPREF0216_01507 | Stage V sporulation protein E; KEGG: hiq:CGSHiGG_09345 5.9e-53 murD; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase K03588; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the SEDS family. | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.799 |
| EKY26961.1 | murD | HMPREF0216_01564 | HMPREF0216_02734 | Stage V sporulation protein E; KEGG: hiq:CGSHiGG_09345 5.9e-53 murD; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase K03588; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the SEDS family. | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.783 |
| EKY26961.1 | murE | HMPREF0216_01564 | HMPREF0216_01561 | Stage V sporulation protein E; KEGG: hiq:CGSHiGG_09345 5.9e-53 murD; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase K03588; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the SEDS family. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.817 |
| EKY26961.1 | murF | HMPREF0216_01564 | HMPREF0216_01562 | Stage V sporulation protein E; KEGG: hiq:CGSHiGG_09345 5.9e-53 murD; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase K03588; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the SEDS family. | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.902 |
| EKY26961.1 | murG | HMPREF0216_01564 | HMPREF0216_00228 | Stage V sporulation protein E; KEGG: hiq:CGSHiGG_09345 5.9e-53 murD; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase K03588; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the SEDS family. | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.736 |
| dapF | murE | HMPREF0216_01578 | HMPREF0216_01561 | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.855 |
| dapF | murF | HMPREF0216_01578 | HMPREF0216_01562 | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.737 |
| glmU | EKY26957.1 | HMPREF0216_00021 | HMPREF0216_01560 | UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | KEGG: cbe:Cbei_1578 2.3e-239 stage V sporulation protein D K08384; Psort location: CytoplasmicMembrane, score: 9.51. | 0.405 |