STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (698 aa)    
Predicted Functional Partners:
EKY29465.1
Pyruvate synthase; KEGG: cbt:CLH_0756 0. nifJ; pyruvate:ferredoxin (flavodoxin) oxidoreductase K03737; Psort location: Cytoplasmic, score: 7.50.
  
   0.999
EKY29370.1
Hypothetical protein; KEGG: cbk:CLL_A0790 9.0e-128 nifJ; pyruvate:ferredoxin (flavodoxin) oxidoreductase K03737.
  
   0.999
EKY25379.1
Pyruvate synthase; KEGG: cdc:CD196_2523 0. nifJ; pyruvate-flavodoxin oxidoreductase; K03737 putative pyruvate-flavodoxin oxidoreductase.
  
   0.999
EKY25396.1
Pyruvate synthase; KEGG: cbt:CLH_2077 0. nifJ; pyruvate:ferredoxin (flavodoxin) oxidoreductase K03737.
  
   0.999
leuS
leucine--tRNA ligase; KEGG: cpf:CPF_0657 0. leuS; leucyl-tRNA synthetase K01869; Psort location: Cytoplasmic, score: 9.97; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
 
 0.983
EKY28185.1
ATP-dependent DNA helicase RecQ.
 
 0.956
EKY22199.1
KEGG: cpe:CPE0343 1.2e-217 recQ; ATP-dependent DNA helicase RecQ; K03654 ATP-dependent DNA helicase RecQ; Psort location: Cytoplasmic, score: 9.89.
 
 0.956
EKY28426.1
Class II glutamine amidotransferase.
  
  
 0.926
polA
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
 0.911
EKY26541.1
DNA protecting protein DprA.
   
 0.879
Your Current Organism:
Clostridium celatum
NCBI taxonomy Id: 545697
Other names: C. celatum DSM 1785, Clostridium celatum DSM 1785
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