STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (499 aa)    
Predicted Functional Partners:
ilvD
KEGG: ccb:Clocel_1323 4.9e-223 dihydroxy-acid dehydratase K01687; Psort location: Cytoplasmic, score: 7.50; Belongs to the IlvD/Edd family.
 
 
 0.987
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
 
 
 0.982
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.979
EKY28532.1
KEGG: cbk:CLL_A0326 5.0e-214 ilvB; acetolactate synthase, large subunit, biosynthetic type K01652; Psort location: Cytoplasmic, score: 9.95.
 
 
 0.957
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 0.950
EKY28538.1
KEGG: cbe:Cbei_0212 6.6e-61 acetolactate synthase, small subunit; K01653 acetolactate synthase I/III small subunit; Psort location: Cytoplasmic, score: 7.50.
 
 
 0.940
EKY23227.1
Branched-chain-amino-acid transaminase; KEGG: ckl:CKL_3620 3.3e-146 ilvE3; branched-chain amino acid aminotransferase K00826; Psort location: Cytoplasmic, score: 7.50.
  
 0.916
EKY29378.1
Aminotransferase, class IV; KEGG: cbt:CLH_0760 8.6e-68 enzyme of IlvE/PabC family; K00826 branched-chain amino acid aminotransferase; Psort location: Cytoplasmic, score: 7.50.
 
 0.912
EKY26133.1
Aminotransferase, class IV; KEGG: cpe:CPE1018 7.1e-64 4-amino-4-deoxychorismate lyase; K02619 4-amino-4-deoxychorismate lyase.
 
 0.904
EKY22089.1
acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
  
 
 0.898
Your Current Organism:
Clostridium celatum
NCBI taxonomy Id: 545697
Other names: C. celatum DSM 1785, Clostridium celatum DSM 1785
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.