close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
luxSS-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (151 aa)    
Predicted Functional Partners:
EKY29331.1
MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
 
 
 0.979
EKY26110.1
KEGG: cbk:CLL_A2853 3.0e-271 5-methyltetrahydrofolate--homocysteine methyltransferase; K00548 5-methyltetrahydrofolate--homocysteine methyltransferase; Psort location: Cytoplasmic, score: 7.50.
 
  
 0.961
EKY26109.1
Vitamin B12 dependent methionine synthase, activation domain protein; KEGG: ctc:CTC01807 1.6e-52 putative 5-methyltetrahydrofolate--homocysteine methyltransferase K00548; Psort location: Cytoplasmic, score: 7.50.
 
  
 0.912
EKY28172.1
Cysteine synthase A.
  
 
 0.891
EKY26107.1
KEGG: cbb:CLD_2935 5.6e-103 metF; 5,10-methylenetetrahydrofolate reductase K00297; Psort location: Cytoplasmic, score: 7.50.
    
 0.880
EKY29278.1
Pyridoxal-phosphate dependent protein; KEGG: cbt:CLH_1484 2.7e-119 cysteine synthase K01738.
  
 
 0.863
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
  
  0.837
EKY28519.1
KEGG: cno:NT01CX_1210 7.0e-160 O-acetylhomoserine/O-acetylserine sulfhydrylase; K01740 O-acetylhomoserine (thiol)-lyase; Psort location: Cytoplasmic, score: 9.67.
     
 0.827
EKY28518.1
KEGG: cdf:CD1580 1.1e-106 hom2; homoserine dehydrogenase K00003; Psort location: Cytoplasmic, score: 7.50.
     
 0.816
EKY24027.1
Threonine ammonia-lyase.
     
 0.816
Your Current Organism:
Clostridium celatum
NCBI taxonomy Id: 545697
Other names: C. celatum DSM 1785, Clostridium celatum DSM 1785
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.