| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EKY22381.1 | EKY24632.1 | HMPREF0216_03269 | HMPREF0216_02662 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Protein FolC; KEGG: cbk:CLL_A2503 7.7e-138 folylpolyglutamate synthase K11754; Psort location: Cytoplasmic, score: 7.50. | 0.511 |
| EKY22381.1 | EKY26131.1 | HMPREF0216_03269 | HMPREF0216_02170 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | KEGG: cbe:Cbei_4120 1.3e-71 glutamine amidotransferase of anthranilate synthase; K01664 para-aminobenzoate synthetase component II; Psort location: Cytoplasmic, score: 7.50. | 0.725 |
| EKY22381.1 | EKY26136.1 | HMPREF0216_03269 | HMPREF0216_02175 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | KEGG: cbe:Cbei_0206 5.9e-92 dihydropteroate synthase K00796; Psort location: Cytoplasmic, score: 7.50. | 0.621 |
| EKY22381.1 | EKY26137.1 | HMPREF0216_03269 | HMPREF0216_02176 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.950 |
| EKY22381.1 | EKY28433.1 | HMPREF0216_03269 | HMPREF0216_00784 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.499 |
| EKY22381.1 | folE | HMPREF0216_03269 | HMPREF0216_02173 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GTP cyclohydrolase I; KEGG: cpf:CPF_1274 9.5e-69 folE; GTP cyclohydrolase I K01495; Psort location: Cytoplasmic, score: 7.50. | 0.632 |
| EKY24632.1 | EKY22381.1 | HMPREF0216_02662 | HMPREF0216_03269 | Protein FolC; KEGG: cbk:CLL_A2503 7.7e-138 folylpolyglutamate synthase K11754; Psort location: Cytoplasmic, score: 7.50. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.511 |
| EKY24632.1 | EKY26136.1 | HMPREF0216_02662 | HMPREF0216_02175 | Protein FolC; KEGG: cbk:CLL_A2503 7.7e-138 folylpolyglutamate synthase K11754; Psort location: Cytoplasmic, score: 7.50. | KEGG: cbe:Cbei_0206 5.9e-92 dihydropteroate synthase K00796; Psort location: Cytoplasmic, score: 7.50. | 0.996 |
| EKY24632.1 | EKY26137.1 | HMPREF0216_02662 | HMPREF0216_02176 | Protein FolC; KEGG: cbk:CLL_A2503 7.7e-138 folylpolyglutamate synthase K11754; Psort location: Cytoplasmic, score: 7.50. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.991 |
| EKY24632.1 | EKY28433.1 | HMPREF0216_02662 | HMPREF0216_00784 | Protein FolC; KEGG: cbk:CLL_A2503 7.7e-138 folylpolyglutamate synthase K11754; Psort location: Cytoplasmic, score: 7.50. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.541 |
| EKY24632.1 | folE | HMPREF0216_02662 | HMPREF0216_02173 | Protein FolC; KEGG: cbk:CLL_A2503 7.7e-138 folylpolyglutamate synthase K11754; Psort location: Cytoplasmic, score: 7.50. | GTP cyclohydrolase I; KEGG: cpf:CPF_1274 9.5e-69 folE; GTP cyclohydrolase I K01495; Psort location: Cytoplasmic, score: 7.50. | 0.670 |
| EKY24632.1 | ribBA | HMPREF0216_02662 | HMPREF0216_00786 | Protein FolC; KEGG: cbk:CLL_A2503 7.7e-138 folylpolyglutamate synthase K11754; Psort location: Cytoplasmic, score: 7.50. | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.465 |
| EKY26131.1 | EKY22381.1 | HMPREF0216_02170 | HMPREF0216_03269 | KEGG: cbe:Cbei_4120 1.3e-71 glutamine amidotransferase of anthranilate synthase; K01664 para-aminobenzoate synthetase component II; Psort location: Cytoplasmic, score: 7.50. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.725 |
| EKY26131.1 | EKY26132.1 | HMPREF0216_02170 | HMPREF0216_02171 | KEGG: cbe:Cbei_4120 1.3e-71 glutamine amidotransferase of anthranilate synthase; K01664 para-aminobenzoate synthetase component II; Psort location: Cytoplasmic, score: 7.50. | Putative aminodeoxychorismate synthase, component I; KEGG: cbe:Cbei_4119 5.3e-146 para-aminobenzoate synthase, subunit I K01665; Psort location: Cytoplasmic, score: 9.67. | 0.999 |
| EKY26131.1 | EKY26133.1 | HMPREF0216_02170 | HMPREF0216_02172 | KEGG: cbe:Cbei_4120 1.3e-71 glutamine amidotransferase of anthranilate synthase; K01664 para-aminobenzoate synthetase component II; Psort location: Cytoplasmic, score: 7.50. | Aminotransferase, class IV; KEGG: cpe:CPE1018 7.1e-64 4-amino-4-deoxychorismate lyase; K02619 4-amino-4-deoxychorismate lyase. | 0.968 |
| EKY26131.1 | EKY26136.1 | HMPREF0216_02170 | HMPREF0216_02175 | KEGG: cbe:Cbei_4120 1.3e-71 glutamine amidotransferase of anthranilate synthase; K01664 para-aminobenzoate synthetase component II; Psort location: Cytoplasmic, score: 7.50. | KEGG: cbe:Cbei_0206 5.9e-92 dihydropteroate synthase K00796; Psort location: Cytoplasmic, score: 7.50. | 0.863 |
| EKY26131.1 | EKY26137.1 | HMPREF0216_02170 | HMPREF0216_02176 | KEGG: cbe:Cbei_4120 1.3e-71 glutamine amidotransferase of anthranilate synthase; K01664 para-aminobenzoate synthetase component II; Psort location: Cytoplasmic, score: 7.50. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.906 |
| EKY26131.1 | folE | HMPREF0216_02170 | HMPREF0216_02173 | KEGG: cbe:Cbei_4120 1.3e-71 glutamine amidotransferase of anthranilate synthase; K01664 para-aminobenzoate synthetase component II; Psort location: Cytoplasmic, score: 7.50. | GTP cyclohydrolase I; KEGG: cpf:CPF_1274 9.5e-69 folE; GTP cyclohydrolase I K01495; Psort location: Cytoplasmic, score: 7.50. | 0.717 |
| EKY26132.1 | EKY26131.1 | HMPREF0216_02171 | HMPREF0216_02170 | Putative aminodeoxychorismate synthase, component I; KEGG: cbe:Cbei_4119 5.3e-146 para-aminobenzoate synthase, subunit I K01665; Psort location: Cytoplasmic, score: 9.67. | KEGG: cbe:Cbei_4120 1.3e-71 glutamine amidotransferase of anthranilate synthase; K01664 para-aminobenzoate synthetase component II; Psort location: Cytoplasmic, score: 7.50. | 0.999 |
| EKY26132.1 | EKY26133.1 | HMPREF0216_02171 | HMPREF0216_02172 | Putative aminodeoxychorismate synthase, component I; KEGG: cbe:Cbei_4119 5.3e-146 para-aminobenzoate synthase, subunit I K01665; Psort location: Cytoplasmic, score: 9.67. | Aminotransferase, class IV; KEGG: cpe:CPE1018 7.1e-64 4-amino-4-deoxychorismate lyase; K02619 4-amino-4-deoxychorismate lyase. | 0.992 |