Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pyrCAmidohydrolase family protein; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (400 aa)    
Predicted Functional Partners:
pyrB
Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 0.999
pyrD
Dihydroorotate dehydrogenase 1B; Catalyzes the conversion of dihydroorotate to orotate.
 
 0.998
carA
KEGG: cbt:CLH_0054 7.5e-156 carA; carbamoyl phosphate synthase small subunit K01956; Psort location: Cytoplasmic, score: 7.50; Belongs to the CarA family.
  
 0.997
carB
KEGG: cbk:CLL_A0071 0. carB; carbamoyl phosphate synthase large subunit K01955; Psort location: Cytoplasmic, score: 9.97; Belongs to the CarB family.
 
 0.997
pyrK
Dihydroorotate dehydrogenase, electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
 
 
 0.995
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
 
 0.975
pyrF
Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily.
 
  
 0.970
EKY27373.1
Putative uracil permease.
  
  
 0.959
EKY28347.1
4Fe-4S binding domain protein; KEGG: tme:Tmel_0121 3.6e-76 dihydroorotate dehydrogenase family protein; K00226 dihydroorotate oxidase; Psort location: Cytoplasmic, score: 9.97.
 
 0.956
EKY26167.1
Aspartate carbamoyltransferase regulatory chain, allosteric domain protein.
    
 0.935
Your Current Organism:
Clostridium celatum
NCBI taxonomy Id: 545697
Other names: C. celatum DSM 1785, Clostridium celatum DSM 1785
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